Journal Article

Transluminal balloon angioplasty for cerebral vasospasm after spontaneous subarachnoid hemorrhage: A single-center experience

Leppert, Jan, Schramm, Peter, Boppel, Tobias, Küchler, Jan, Neumann, Alexander, Ditz, Claudia, Schacht, Hannes

2020

Overview

After spontaneous subarachnoid hemorrhage (sSAH), cerebral vasospasm (CVS) is a common complication, potentially resulting in infarction mainly responsible for a poor outcome. Intra-arterial vasodilators lead to transient increase of brain perfusion, but only transluminal balloon angioplasty (TBA) promises longer-lasting effects, though it poses the risk of severe complications. Until now, the precise impact of TBA on the course of CVS is not yet finally clarified. Thus we aimed to identify risk factors of recurrent CVS and vasospasm-related infarction following TBA. We analyzed 35 patients with CVS after sSAH who received TBA (41 procedures, 99 vessel segments). Gender, age, WFNS grade and Fisher scale, occurrence of intraventricular and intracerebral hemorrhage, localization of the aneurysm and the initial treatment modality were obtained. We assessed functional outcome after 3 months and in-hospital mortality. TBA was analyzed concerning time point, localization, technique, complications and angiographic response. Furthermore, recurrence of CVS and vasospasm-related infarction after TBA were described and risk factors were identified with logistic regression analyses. In 7 of 35 patients (20%) and in 16 of 99 vessel segments (16%) previously treated with TBA, we found recurrent CVS. Vasospasm-related infarction occurred in 18 cases (18%) in the arterial territories of the TBA-treated vessel segments. The angiographic effect after TBA was mostly classified as good (87%), good response was negatively associated with recurrent CVS (p = 0.004) and vasospasm-related infarction (p = 0.001). We identified only the male gender as a risk factor for vasospasm-related infarction after TBA (p = 0.040). In connection with TBA, only one complication occurred (intracranial dissection). Our data support TBA as a safe and effective therapy for CVS. Nevertheless, recurrent CVS and vasospasm-related infarction were common after TBA and not predictable by clinical conditions on admission or the localization of CVS. A moderate or poor angiographic response after TBA was identified as a risk factor for both, recurrent CVS and vasospasm-related infarction, while male gender was associated with a higher risk of vasospasm-related infarction. Our results augment the still sparse evidence concerning optimal patient selection for this method and provide new aspects for individual therapy decisions.

• Publisher: Elsevier B.V,Elsevier Limited
• Subject: Adult / Aneurysms / Angioplasty / Angioplasty, Balloon - methods / Balloon treatment / Brain Infarction - epidemiology / Brain Infarction - etiology / Brain Infarction - prevention & control / Brain Ischemia - epidemiology / Brain Ischemia - etiology / Brain Ischemia - prevention & control / Catheters / Cerebral Angiography / Cerebral infarction / Cerebral vasospasm / Delayed cerebral ischemia / Endovascular Procedures / Endovascular treatment / Female / Hemorrhage / Humans / Injections, Intra-Arterial / Ischemia / Localization / Male / Middle Aged / Neurology / Neurosurgery / Nimodipine - therapeutic use / Patients / Perfusion / Risk Factors / Sex Factors / Stroke / Subarachnoid hemorrhage / Subarachnoid Hemorrhage - complications / Subarachnoid Hemorrhage - therapy / Transluminal balloon angioplasty / Treatment Outcome / Vasoconstriction / Vasodilator Agents - therapeutic use / Vasodilators / Vasospasm, Intracranial - etiology / Vasospasm, Intracranial - therapy