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Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions
by
Heideman, Daniëlle A M
, Steenbergen, Renske D M
, Snijders, Peter J F
, Meijer, Chris J L M
in
Biomarkers, Tumor - genetics
/ Cell Transformation, Neoplastic
/ Cervical Intraepithelial Neoplasia - genetics
/ Cervical Intraepithelial Neoplasia - pathology
/ Cervical Intraepithelial Neoplasia - virology
/ Cervix diseases
/ Epigenomics
/ Female
/ Genetic aspects
/ Genetic research
/ Genetic transformation
/ Humans
/ Papillomaviridae - pathogenicity
/ Papillomavirus infections
/ Papillomavirus Infections - genetics
/ Papillomavirus Infections - pathology
/ Papillomavirus Infections - virology
/ Precancerous Conditions - genetics
/ Precancerous Conditions - pathology
/ Precancerous Conditions - virology
/ Uterine Cervical Neoplasms - genetics
/ Uterine Cervical Neoplasms - pathology
/ Uterine Cervical Neoplasms - virology
2014
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Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions
by
Heideman, Daniëlle A M
, Steenbergen, Renske D M
, Snijders, Peter J F
, Meijer, Chris J L M
in
Biomarkers, Tumor - genetics
/ Cell Transformation, Neoplastic
/ Cervical Intraepithelial Neoplasia - genetics
/ Cervical Intraepithelial Neoplasia - pathology
/ Cervical Intraepithelial Neoplasia - virology
/ Cervix diseases
/ Epigenomics
/ Female
/ Genetic aspects
/ Genetic research
/ Genetic transformation
/ Humans
/ Papillomaviridae - pathogenicity
/ Papillomavirus infections
/ Papillomavirus Infections - genetics
/ Papillomavirus Infections - pathology
/ Papillomavirus Infections - virology
/ Precancerous Conditions - genetics
/ Precancerous Conditions - pathology
/ Precancerous Conditions - virology
/ Uterine Cervical Neoplasms - genetics
/ Uterine Cervical Neoplasms - pathology
/ Uterine Cervical Neoplasms - virology
2014
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Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions
by
Heideman, Daniëlle A M
, Steenbergen, Renske D M
, Snijders, Peter J F
, Meijer, Chris J L M
in
Biomarkers, Tumor - genetics
/ Cell Transformation, Neoplastic
/ Cervical Intraepithelial Neoplasia - genetics
/ Cervical Intraepithelial Neoplasia - pathology
/ Cervical Intraepithelial Neoplasia - virology
/ Cervix diseases
/ Epigenomics
/ Female
/ Genetic aspects
/ Genetic research
/ Genetic transformation
/ Humans
/ Papillomaviridae - pathogenicity
/ Papillomavirus infections
/ Papillomavirus Infections - genetics
/ Papillomavirus Infections - pathology
/ Papillomavirus Infections - virology
/ Precancerous Conditions - genetics
/ Precancerous Conditions - pathology
/ Precancerous Conditions - virology
/ Uterine Cervical Neoplasms - genetics
/ Uterine Cervical Neoplasms - pathology
/ Uterine Cervical Neoplasms - virology
2014
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Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions
Journal Article
Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions
2014
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Overview
Infection of cervical epithelium with high-risk human papilloma virus (hrHPV) might result in productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of which can overlap. In transforming CIN lesions, aberrations in host cell genes accumulate over time, which is necessary for the ultimate progression to cancer. On the basis of (epi)genetic changes, early and advanced transforming CIN lesions can be distinguished. This paves the way for new molecular tools for cervical screening, diagnosis and management of cervical cancer precursor lesions.
Publisher
Nature Publishing Group
Subject
/ Cell Transformation, Neoplastic
/ Cervical Intraepithelial Neoplasia - genetics
/ Cervical Intraepithelial Neoplasia - pathology
/ Cervical Intraepithelial Neoplasia - virology
/ Female
/ Humans
/ Papillomaviridae - pathogenicity
/ Papillomavirus Infections - genetics
/ Papillomavirus Infections - pathology
/ Papillomavirus Infections - virology
/ Precancerous Conditions - genetics
/ Precancerous Conditions - pathology
/ Precancerous Conditions - virology
/ Uterine Cervical Neoplasms - genetics
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