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Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray
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Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray
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Journal Article
Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray
2018
Overview
The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, which led to the isolation of two new sesquiterpene alkaloids (1 and 2) and six known furanosesquiterpenes (3–8). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids (1 and 2) displayed potent anti-MRSA activity with MIC value of 6.25 μg/mL. This is the first report of sesquiterpene alkaloids from the plants of Myoporum genus and their anti-MRSA activity.
Publisher
MDPI AG,MDPI
Subject
/ Alkaloids - isolation & purification
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - isolation & purification
/ Anti-Bacterial Agents - pharmacology
/ Carbon
/ Drug Evaluation, Preclinical
/ methicillin-resistant Staphylococcus aureus (MRSA)
/ Methicillin-Resistant Staphylococcus aureus - drug effects
/ Myoporum
/ NMR
/ Sesquiterpenes - isolation & purification
/ Sesquiterpenes - pharmacology
/ Wetlands
