Journal Article

Surgical management of complex mediastinitis: an 8-year single-centre experience reinforcing the role of open thoracotomy

Santos, Felix, Bille, Andrea, Lampridis, Savvas, Curti, Fabiana, Berjaoui, Nabih, Chan, Puiyee Sophia, Patel, Akshay

2025

Overview

Abstract OBJECTIVES Mediastinitis is an infection affecting the mediastinum, often caused by cardiovascular or thoracic surgery procedures. Management entails antibiotic therapy, surgical debridement, drainage of infected sites and immediate or delayed closure. Negative pressure wound therapy is useful in cases of delayed sternal closure. Several approaches for mediastinal drainage have been proposed, but there is no consensus on the thoracic intervention approach. METHODS A single-centre, retrospective analysis from the UK analysed data from 19 patients who underwent surgical management for mediastinitis between September 2015 and April 2023. Our primary aim was to describe the outcomes from our series where we predominantly employed an open surgical approach. RESULTS The mean age of our cohort was 49 ± 17.12 years old; the mean performance status (PS ECOG) was 2 ± 0.77. Two people were known smokers (10.53%), while five were non-smokers (26.31%). Fifteen patients underwent an open operation (78.85%), with rest undergoing a minimally invasive approach. The majority of procedures were undertaken from the right-hand side. The overall intensive care unit admission rate was 68.42% (n = 13) with an in-hospital complication rate of 5.26% (n = 1). This was a respiratory arrest secondary to mucous plugging. There were no in-hospital deaths, and median follow-up was 41 months (22–50). Overall survival at 3 years was 85%. CONCLUSIONS Open thoracotomy remains an important surgical strategy in the management of complex mediastinitis, but further validation is required through larger, prospective studies. Mediastinitis is a rare but life-threatening condition that may result from deep sternal wound infection (DSWI), oesophageal perforation or descending necrotizing mediastinitis (DNM) [1]. GRAPHICAL ABSTRACT

• Publisher: Oxford University Press,Oxford Publishing Limited (England)
• Subject: Adult / Aged / Debridement - adverse effects / Debridement - mortality / Drainage - adverse effects / Drainage - mortality / Female / Humans / Male / Mediastinitis - diagnosis / Mediastinitis - microbiology / Mediastinitis - mortality / Mediastinitis - surgery / Middle Aged / Negative-Pressure Wound Therapy / Ostomy / Retrospective Studies / Thoracic Non-oncology / Thoracic surgery / Thoracotomy - adverse effects / Thoracotomy - methods / Thoracotomy - mortality / Time Factors / Treatment Outcome