Asset Details
Do you wish to reserve the book?
White Matter Changes Associated with Antipsychotic Treatment in First-Episode Psychosis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
White Matter Changes Associated with Antipsychotic Treatment in First-Episode Psychosis
Do you wish to request the book?
White Matter Changes Associated with Antipsychotic Treatment in First-Episode Psychosis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
White Matter Changes Associated with Antipsychotic Treatment in First-Episode Psychosis
2014
Overview
Second-generation antipsychotics are utilized extensively in the treatment of psychotic disorders and other psychiatric conditions, but the effects of these medications on human brain white matter are not well understood. We thus investigated the effects of second-generation antipsychotics on white matter integrity using tract-based spatial statistics in patients experiencing a first episode of psychosis with little or no prior antipsychotic exposure, and how potential changes were associated with metabolic side effects. Thirty-five (26 men/9 women) patients experiencing a first episode of psychosis received diffusion tensor imaging (DTI) exams, clinical assessments, and provided fasting blood samples at the onset of antipsychotic treatment, and then again after 12 weeks of treatment with either risperidone or aripiprazole in a double-blind randomized clinical trial. In addition, 35 (26 men/9 women) healthy volunteers received DTI exams at a baseline time point and then after 12 weeks. Patients demonstrated significant (p<0.05; family-wise error corrected) fractional anisotropy reductions within the parietal and occipital white matter following antipsychotic treatment. Greater overall fractional anisotropy reduction was significantly correlated with greater increases in low-density lipoprotein. There were no significant fractional anisotropy increases among patients following treatment. Moreover, healthy volunteers did not demonstrate either significant increases or decreases in fractional anisotropy across a comparable 12-week interval. The use of antipsychotics may be associated with a subtle loss of white matter integrity that is related to greater side effects, thus raising potentially important considerations regarding risk/benefit in their usage. Limitations of the current study, however, include a prior history of substance use among patients and our inability to exclude the possibility of disease progression.
Publisher
Nature Publishing Group
Subject
/ Antipsychotic Agents - therapeutic use
/ Biological and medical sciences
/ Female
/ Humans
/ Male
/ Nerve Fibers, Myelinated - drug effects
/ Nerve Fibers, Myelinated - pathology
/ Occipital Lobe - drug effects
/ Original
/ Parietal Lobe - drug effects
/ Pharmacology. Drug treatments
/ Piperazines - therapeutic use
/ Psycholeptics: tranquillizer, neuroleptic
/ Psychology. Psychoanalysis. Psychiatry
/ Psychotic Disorders - drug therapy
/ Psychotic Disorders - pathology
/ Quinolones - therapeutic use
