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Prenatal Findings in Congenital Leukemia: A Case Report

by Kakui, Kazuyo , Tatsumi, Keiji , Mikami, Yoshiki , Minegishi, Katsura , Fujiwara, Hiroshi , Sato, Yukiyasu , Konishi, Ikuo , Izumi, Yukiko , Komada, Munekazu , Yamada, Shigehito

in Biological and medical sciences / Cesarean Section / Chorionic Villi - pathology / Delivery. Postpartum. Lactation / Fatal Outcome / Female / Fetal Diseases - pathology / Fetal Diseases - physiopathology / General aspects / Gestational Age / Gynecology. Andrology. Obstetrics / Hematologic and hematopoietic diseases / Humans / Leukemia, Myeloid - congenital / Leukemia, Myeloid - pathology / Leukemia, Myeloid - physiopathology / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Male / Medical sciences / Novel Insights from Clinical Practice / Pleural Effusion / Pregnancy / Pulsatile Flow / Stillbirth / Umbilical Arteries - physiopathology / Umbilical Cord - pathology

2011

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Prenatal Findings in Congenital Leukemia: A Case Report

by Kakui, Kazuyo , Tatsumi, Keiji , Mikami, Yoshiki , Minegishi, Katsura , Fujiwara, Hiroshi , Sato, Yukiyasu , Konishi, Ikuo , Izumi, Yukiko , Komada, Munekazu , Yamada, Shigehito

2011

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Prenatal Findings in Congenital Leukemia: A Case Report

by Kakui, Kazuyo , Tatsumi, Keiji , Mikami, Yoshiki , Minegishi, Katsura , Fujiwara, Hiroshi , Sato, Yukiyasu , Konishi, Ikuo , Izumi, Yukiko , Komada, Munekazu , Yamada, Shigehito

2011

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Journal Article

Prenatal Findings in Congenital Leukemia: A Case Report

Kakui, Kazuyo,

Tatsumi, Keiji,

Mikami, Yoshiki,

Minegishi, Katsura,

Fujiwara, Hiroshi,

Sato, Yukiyasu,

Konishi, Ikuo,

Izumi, Yukiko,

Komada, Munekazu,

Yamada, Shigehito

2011

Overview

We here describe a case of congenital leukemia that ended in intrauterine fetal demise at 30 weeks of gestation. Acute enlargement of the fetal trunk, elevated pulsatility index of the umbilical artery with concomitant decline of pulsatility index of the middle cerebral artery, pleural effusion, and polyhydramnios preceded the fetal death. Diagnosis of congenital myeloid leukemia was suggested by microscopic examination of the placental tissue, revealing immature myeloid precursors filling the lumina of fetal vessels in the umbilical cord and chorionic villi. Extensive vascular involvement of the placenta by leukemic cells was considered to be a primary cause of the fetal death.

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Publisher

Karger,S. Karger AG

Subject

Biological and medical sciences

/ Cesarean Section

/ Chorionic Villi - pathology

/ Delivery. Postpartum. Lactation

/ Fatal Outcome

/ Female

/ Fetal Diseases - pathology