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Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

by Gallego Ferrer, Gloria , García-Briega, María Inmaculada , Ródenas-Rochina, Joaquín , Martins, Luis Amaro , Lanceros-Méndez, Senentxu , Gómez Ribelles, José Luís , Sempere, Amparo

in Acids / Algae / Alginates / Biodegradation / Biomimetics / Biomolecules / Bioreactors / Cell culture / Cellular structure / Crosslinking / Equilibrium / Ethylenediaminetetraacetic acid / Heparin / Hydrogels / Microgels / Microspheres / Multilayers / Multiple myeloma / Phenols / Polyelectrolytes / Sodium

2022

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Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

by Gallego Ferrer, Gloria , García-Briega, María Inmaculada , Ródenas-Rochina, Joaquín , Martins, Luis Amaro , Lanceros-Méndez, Senentxu , Gómez Ribelles, José Luís , Sempere, Amparo

2022

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Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

by Gallego Ferrer, Gloria , García-Briega, María Inmaculada , Ródenas-Rochina, Joaquín , Martins, Luis Amaro , Lanceros-Méndez, Senentxu , Gómez Ribelles, José Luís , Sempere, Amparo

2022

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Journal Article

Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

Gallego Ferrer, Gloria,

García-Briega, María Inmaculada,

Ródenas-Rochina, Joaquín,

Martins, Luis Amaro,

Lanceros-Méndez, Senentxu,

Gómez Ribelles, José Luís,

Sempere, Amparo

2022

Overview

Alginate hydrogels can be used to develop a three-dimensional environment in which various cell types can be grown. Cross-linking the alginate chains using reversible ionic bonds opens up great possibilities for the encapsulation and subsequent release of cells or drugs. However, alginate also has a drawback in that its structure is not very stable in a culture medium with cellular activity. This work explored the stability of alginate microspheres functionalised by grafting specific biomolecules onto their surface to form microgels in which biomimetic microspheres surrounded the cells in the culture, reproducing the natural microenvironment. A study was made of the stability of the microgel in different typical culture media and the formation of polyelectrolyte multilayers containing polylysine and heparin. Multiple myeloma cell proliferation in the culture was tested in a bioreactor under gentle agitation.

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MDPI AG,MDPI

Subject

/ Algae