Journal Article

BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study

Armstrong, D K, Zahn, C, Birrer, M J, Lesnock, J L, DeLoia, J A, Thrall, M M, Krivak, T C, Darcy, K M, Tian, C

2013

Overview

Background: Breast cancer 1, early onset ( BRCA1 ) is a tumour-suppressor gene associated with familial epithelial ovarian cancer (EOC). Reduced BRCA1 expression is associated with enhanced sensitivity to platinum-based chemotherapy. We sought to examine the prognostic relevance of BRCA1 expression in EOC patients treated with intraperitoneal platinum/taxane. Methods: The GOG-172 was a phase III, multi-institutional randomised trial of intravenous paclitaxel and cisplatin (IV therapy) vs intravenous paclitaxel, intraperitoneal cisplatin plus paclitaxel (IP therapy) in patients with optimally resected stage III EOC. The BRCA1 expression was assessed with immunohistochemistry (IHC) staining blinded to clinical outcome in archival tumour specimens. Slides with ⩽10% staining were defined as aberrant and >10% as normal. Correlations between BRCA1 expression and progression-free survival (PFS) and overall survival (OS) were analysed using Kaplan–Meier method and Cox regression analysis. Results: Of the 393 patients, 189 tumours had aberrant expression, and 204 had normal BRCA1 expression. There was an interaction between BRCA1 expression and route of administration on OS ( P =0.014) but not PFS ( P =0.054). In tumours with normal BRCA1 expression, the median OS was 58 months for IP group vs 50 months for IV group ( P =0.818). In tumours with aberrant BRCA1 expression, the median OS was 84 vs 47 months in the IP vs IV group, respectively ( P =0.0002). Aberrant BRCA1 expression was an independent prognostic factor for better survival in women randomised to IP therapy (hazard ratio (HR)=0.67, 95% confidence interval (CI)=0.47–0.97, P =0.032). Similar survival was observed in the IV and IP patients with normal BRCA1 expression. Multivariate but not univariate modelling demonstrated that IV patients with aberrant vs normal BRCA1 expression had worse survival. Conclusion: Decreased BRCA1 expression is associated with a 36-month survival improvement in patients with EOC treated with IP chemotherapy. Although these results merit validation in future studies, the results suggest that decreased BRCA1 expression predicts for improved response to cisplatin-based IP chemotherapy with cisplatin and paclitaxel.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 692/53/2422 / 692/699/67/1059/99 / 692/699/67/1517/1709 / Adenocarcinoma, Clear Cell - drug therapy / Adenocarcinoma, Clear Cell - metabolism / Adenocarcinoma, Clear Cell - mortality / Adenocarcinoma, Mucinous - drug therapy / Adenocarcinoma, Mucinous - metabolism / Adenocarcinoma, Mucinous - mortality / Adult / Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / BRCA1 Protein - metabolism / Cancer Research / Cisplatin - administration & dosage / Clinical Study / Cystadenocarcinoma, Serous - drug therapy / Cystadenocarcinoma, Serous - metabolism / Cystadenocarcinoma, Serous - mortality / Drug Resistance / Endometrial Neoplasms - drug therapy / Endometrial Neoplasms - metabolism / Endometrial Neoplasms - mortality / Epidemiology / Female / Female genital diseases / Follow-Up Studies / Gynecology. Andrology. Obstetrics / Humans / Immunoenzyme Techniques / Injections, Intraperitoneal / Medical sciences / Middle Aged / Molecular Medicine / Neoplasm Staging / Oncology / Ovarian cancer / Ovarian Neoplasms - drug therapy / Ovarian Neoplasms - metabolism / Ovarian Neoplasms - mortality / Paclitaxel - administration & dosage / Prognosis / Survival Rate / Tumors