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A global non-coding RNA system modulates fission yeast protein levels in response to stress
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A global non-coding RNA system modulates fission yeast protein levels in response to stress
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Journal Article
A global non-coding RNA system modulates fission yeast protein levels in response to stress
2014
Overview
Non-coding RNAs (ncRNAs) are frequent and prevalent across the taxa. Although individual non-coding loci have been assigned a function, most are uncharacterized. Their global biological significance is unproven and remains controversial. Here we investigate the role played by ncRNAs in the stress response of
Schizosaccharomyces pombe
. We integrate global proteomics and RNA sequencing data to identify a systematic programme in which elevated antisense RNA arising both from ncRNAs and from 3′-overlapping convergent gene pairs is directly associated with substantial reductions in protein levels throughout the genome. We describe an extensive array of ncRNAs with
trans
associations that have the potential to influence multiple pathways. Deletion of one such locus reduces levels of
atf1
, a transcription factor downstream of the stress-activated mitogen-activated protein kinase (MAPK) pathway, and alters sensitivity to oxidative stress. These non-coding transcripts therefore regulate specific stress responses, adding unanticipated information-processing capacity to the MAPK signalling system.
Non-coding RNAs are widely expressed, yet their functions remain poorly understood. Here, Leong
et al
. identify a set of antisense RNAs elevated during the yeast stress response that directly correlate with reduced protein levels, indicating a general regulatory effect of antisense expression.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
/ 82
/ 82/58
/ Gene Expression Regulation, Fungal
/ Humanities and Social Sciences
/ Open Reading Frames - genetics
/ RNA, Untranslated - genetics
/ RNA, Untranslated - metabolism
/ Schizosaccharomyces - genetics
/ Schizosaccharomyces pombe Proteins - genetics
/ Schizosaccharomyces pombe Proteins - metabolism
/ Science
/ Stress, Physiological - genetics
/ Yeasts
