Journal Article

Clinical characteristics and outcomes of aortic prosthetic valve endocarditis: comparison between transcatheter and surgical bioprostheses

Cuervo, Guillermo, Cabezón, Gonzalo, Anguita, Manuel, Vilacosta, Isidre, Escrihuela-Vidal, Francesc, Ramos, Antonio, López, Javier, Sáez, Carmen, Olmos, Carmen, Álvarez Rodríguez, Jesús, Carlos Castillo, Juan, Jerónimo, Adrián, Calderón-Parra, Jorge, Pulido, Paloma, Gómez-Ramírez, Daniel, de Miguel-Álava, María, Zulet, Pablo, San Román, J. Alberto

2024

Overview

Purpose Most data regarding infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) comes from TAVI registries, rather than IE dedicated cohorts. The objective of our study was to compare the clinical and microbiological profile, imaging features and outcomes of patients with IE after SAVR with a biological prosthetic valve (IE-SAVR) and IE after TAVI (IE-TAVI) from 6 centres with an Endocarditis Team (ET) and broad experience in IE. Methods Retrospective analysis of prospectively collected data. From the time of first TAVI implantation in each centre to March 2021, all consecutive patients admitted for IE-SAVR or IE-TAVI were prospectively enrolled. Follow-up was monitored during admission and at 12 months after discharge. Results 169 patients with IE-SAVR and 41 with IE-TAVI were analysed. Early episodes were more frequent among IE-TAVI. Clinical course during hospitalization was similar in both groups, except for a higher incidence of atrioventricular block in IE-SAVR. The most frequently causative microorganisms were S. epidermidis , Enterococcus spp. and S. aureus in both groups. Periannular complications were more frequent in IE-SAVR. Cardiac surgery was performed in 53.6% of IE-SAVR and 7.3% of IE-TAVI (p=0.001), despite up to 54.8% of IE-TAVI patients had an indication. No differences were observed about death during hospitalization (32.7% vs 35.0%), and at 1-year follow-up (41.8% vs 37.5%), regardless of whether the patient underwent surgery or not. Conclusion Patients with IE-TAVI had a higher incidence of early prosthetic valve IE. Compared to IE-SAVR, IE-TAVI patients underwent cardiac surgery much less frequently, despite having surgical indications. However, in-hospital and 1-year mortality rate was similar between both groups.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Aged / Aged, 80 and over / Aorta / Aortic valve / Aortic Valve - surgery / Bioprosthesis - adverse effects / Bioprosthesis - microbiology / Data collection / death / disease course / Endocarditis / Endocarditis - microbiology / Endocarditis, Bacterial - microbiology / Enterococcus / Family Medicine / Female / General Practice / Heart surgery / Heart Valve Prosthesis - adverse effects / Heart Valve Prosthesis - microbiology / Heart valves / Humans / Implantation / infection / Infectious Diseases / Internal Medicine / Male / Medicine / Medicine & Public Health / Microorganisms / mortality / Patients / Prostheses / Prosthesis-Related Infections - microbiology / Retrospective Studies / Staphylococcus epidermidis / Surgery / Transcatheter Aortic Valve Replacement - adverse effects / Treatment Outcome