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47-Year-Old Man With Pancytopenia and Fever
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47-Year-Old Man With Pancytopenia and Fever
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Journal Article
47-Year-Old Man With Pancytopenia and Fever
2019
Overview
Results were also notable for leukopenia, with a low absolute neutrophil count of 0.10 x 109/L (reference range, 1.70-7.00 x 109/L). Because of concern about underlying malignancy, a bone marrow biopsy was obtained, but no abnormalities were identified. Hematologic malignancy is the most likely diagnosis to explain the patient's presentation. Because of his history of FS, the patient is at high risk for malignancy. [...]although paroxysmal nocturnal hemoglobinuria could explain the patient's hemolytic anemia, he does not have other classic features of this disorder including venous thromboemboli or recurrent abdominal pain.5 With concern for underlying malignancy, and because of progressive pancytopenia and weight loss of 9 kg over the course of 2 months, the patient was transferred to our hospital for further work-up. Because of the wellestablished cardiotoxicity secondary to anthracyclines, such as doxorubicin, baseline transthoracic echocardiography must be obtained before treatment.13 The patient underwent transthoracic echocardiography before initiation of CHOEP chemotherapy, which showed a preserved left ventricular ejection fraction of 68%.
Publisher
Elsevier Inc,Frontline Medical Communications Inc,Elsevier Limited
Subject
/ Anemia
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Biopsy
/ Blood
/ Cyclophosphamide - therapeutic use
/ Doxorubicin - therapeutic use
/ Fever
/ Heart
/ Humans
/ Jaundice
/ Leukemia
/ Lymphoma
/ Lymphoma, T-Cell - diagnosis
/ Lymphoma, T-Cell - drug therapy
/ Male
/ Methylprednisolone - therapeutic use
/ Pain
/ Paroxysmal nocturnal hemoglobinuria
/ Patients
/ Peptides
/ Prednisolone - therapeutic use
/ Rash
