Asset Details
Do you wish to reserve the book?
Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle
Do you wish to request the book?
Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle
2013
Overview
Our previous experiments demonstrated that systemic depletion of serotonin (5-hydroxytryptamine, 5-HT), similar to levels reported in patients with emotional disorders, enhanced glutamateric activity in the lateral nucleus of the amygdala (LA) and potentiated fear behaviors. However, the effects of isolated depletion of 5-HT in the LA, and the molecular mechanisms underlying enhanced glutamatergic activity are unknown. In the present study, we tested the hypothesis that depletion of 5-HT in the LA induces increased fear behavior, and concomitantly enhances glutamate receptor (GluR) expression. Bilateral infusions of 5,7-dihydroxytryptamine (4 μg per side) into the LA produced a regional reduction of serotonergic fibers, resulting in decreased 5-HT concentrations. The induction of low 5-HT in the LA elevated fear-potentiated startle, with a parallel increase in GluR1 mRNA and GluR1 protein expression. These findings suggest that low 5-HT concentrations in the LA may facilitate fear behavior through enhanced GluR-mediated mechanisms. Moreover, our data support a relationship between 5-HT and glutamate in psychopathologies.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
5,7-Dihydroxytryptamine - pharmacology
/ Animals
/ Behavior, Animal - drug effects
/ Behavior, Animal - physiology
/ Medicine
/ Original
/ Rats
/ Receptors, AMPA - drug effects
/ Receptors, AMPA - metabolism
/ Reflex, Startle - drug effects
/ Reflex, Startle - physiology
