Journal Article

Visual ensemble selection of deep convolutional neural networks for 3D segmentation of breast tumors on dynamic contrast enhanced MRI

Rahimpour, Masoomeh, Frouin, Frédérique, Saint Martin, Marie-Judith, Koole, Michel, Malhaire, Caroline, Orlhac, Fanny, Akl, Pia

2023

Overview

Objectives To develop a visual ensemble selection of deep convolutional neural networks (CNN) for 3D segmentation of breast tumors using T1-weighted dynamic contrast-enhanced (T1-DCE) MRI. Methods Multi-center 3D T1-DCE MRI ( n = 141) were acquired for a cohort of patients diagnosed with locally advanced or aggressive breast cancer. Tumor lesions of 111 scans were equally divided between two radiologists and segmented for training. The additional 30 scans were segmented independently by both radiologists for testing. Three 3D U-Net models were trained using either post-contrast images or a combination of post-contrast and subtraction images fused at either the image or the feature level. Segmentation accuracy was evaluated quantitatively using the Dice similarity coefficient (DSC) and the Hausdorff distance (HD95) and scored qualitatively by a radiologist as excellent, useful, helpful, or unacceptable. Based on this score, a visual ensemble approach selecting the best segmentation among these three models was proposed. Results The mean and standard deviation of DSC and HD95 between the two radiologists were equal to 77.8 ± 10.0% and 5.2 ± 5.9 mm. Using the visual ensemble selection, a DSC and HD95 equal to 78.1 ± 16.2% and 14.1 ± 40.8 mm was reached. The qualitative assessment was excellent (resp. excellent or useful) in 50% (resp. 77%). Conclusion Using subtraction images in addition to post-contrast images provided complementary information for 3D segmentation of breast lesions by CNN. A visual ensemble selection allowing the radiologist to select the most optimal segmentation obtained by the three 3D U-Net models achieved comparable results to inter-radiologist agreement, yielding 77% segmented volumes considered excellent or useful. Key Points • Deep convolutional neural networks were developed using T1-weighted post-contrast and subtraction MRI to perform automated 3D segmentation of breast tumors. • A visual ensemble selection allowing the radiologist to choose the best segmentation among the three 3D U-Net models outperformed each of the three models. • The visual ensemble selection provided clinically useful segmentations in 77% of cases, potentially allowing for a valuable reduction of the manual 3D segmentation workload for the radiologist and greatly facilitating quantitative studies on non-invasive biomarker in breast MRI.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V,Springer Verlag
• Subject: Artificial neural networks / Bioengineering / Biomarkers / Breast - pathology / Breast cancer / Breast Neoplasms - diagnostic imaging / Breast Neoplasms - pathology / Computer Science / Diagnostic Radiology / Female / Humans / Image contrast / Image processing / Image Processing, Computer-Assisted - methods / Image segmentation / Imaging / Imaging Informatics and Artificial Intelligence / Internal Medicine / Interventional Radiology / Lesions / Life Sciences / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Medical imaging / Medicine / Medicine & Public Health / Metric space / Neural networks / Neural Networks, Computer / Neuroradiology / Radiology / Three dimensional models / Tumors / Ultrasound