Asset Details
Do you wish to reserve the book?
2,3-Dihydroxybenzoic Acid Electrospun into Poly(d,l-lactide) (PDLLA)/Poly(ethylene oxide) (PEO) Nanofibers Inhibited the Growth of Gram-Positive and Gram-Negative Bacteria
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
2,3-Dihydroxybenzoic Acid Electrospun into Poly(d,l-lactide) (PDLLA)/Poly(ethylene oxide) (PEO) Nanofibers Inhibited the Growth of Gram-Positive and Gram-Negative Bacteria
Do you wish to request the book?
2,3-Dihydroxybenzoic Acid Electrospun into Poly(d,l-lactide) (PDLLA)/Poly(ethylene oxide) (PEO) Nanofibers Inhibited the Growth of Gram-Positive and Gram-Negative Bacteria
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
2,3-Dihydroxybenzoic Acid Electrospun into Poly(d,l-lactide) (PDLLA)/Poly(ethylene oxide) (PEO) Nanofibers Inhibited the Growth of Gram-Positive and Gram-Negative Bacteria
2014
Overview
Widespread emergence of antibiotic-resistant pathogens in recent years has restricted the treatment options for various infectious diseases. Investigation of alternative antimicrobial agents and therapies is thus of utmost importance. Electrospinning of 50 mg/ml 2,3-dihydroxybenzoic acid (DHBA) into 24 % (w/v) poly(
d
,
l
-lactide) (PDLLA) and poly(ethylene oxide) (PEO) (1:1) produced nanofibers with an average diameter of 401 ± 122 nm. DHBA released from the nanofibers (315 ± 0.04 µg/ml within 2 h) inhibited the growth of
Pseudomonas aeruginosa
Xen 5,
Klebsiella pneumoniae
Xen 39,
Escherichia coli
Xen 14,
Salmonella typhimurium
Xen 26, and
Staphylococcus aureus
strains Xen 30, Xen 31, and Xen 36. The reason for the rapid diffusion of DHBA from PEO:PDLLA may be due to formation of hydrogen bonds between the hydroxyl groups of DHBA and the C=O groups of the PDLLA. DHBA formed a strong interaction with PDLLA and increased the thermal stability of the nanofiber mesh. The DHBA-containing nanofibers were non-hemolytic, suggesting that they may be incorporated in the development of a wound dressing.
Publisher
Springer US,Springer Nature B.V
Subject
Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - toxicity
/ Bacteria
/ Biomedical and Life Sciences
/ E coli
/ Gram-Negative Bacteria - drug effects
/ Gram-Negative Bacteria - growth & development
/ Hydroxybenzoates - pharmacology
/ Microscopy, Electron, Scanning
/ Polyethylene Glycols - pharmacology
/ Polyethylene Glycols - toxicity
/ Polymers
/ Staphylococcus aureus - drug effects
