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Symptomatic and physiologic outcomes one year after peroral esophageal myotomy (POEM) for treatment of achalasia
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Symptomatic and physiologic outcomes one year after peroral esophageal myotomy (POEM) for treatment of achalasia
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Journal Article
Symptomatic and physiologic outcomes one year after peroral esophageal myotomy (POEM) for treatment of achalasia
2014
Overview
Background
Peroral esophageal myotomy (POEM) is a new endoscopic operation for the treatment of achalasia. Here, we report 1-year physiologic and symptomatic outcomes following the procedure.
Methods
POEM patients from a single-institution series who were more than 1 year removed from surgery were studied. Eckardt and GerdQ scores were obtained to assess symptoms. High-resolution manometry (HRM), timed barium esophagram (TBE), and upper endoscopy were preformed preoperatively and at 1-year follow-up. 24-h pH monitoring was also performed at 1 year follow-up.
Results
The study population was comprised of 41 patients who were more than 1 year post-POEM. One (2 %) major complication, a contained leak at the EGJ requiring re-operation, and 7 (17 %) minor complications occurred. Mean length of stay was 1.4 days. At mean 15-month follow-up, Eckardt scores improved from pre-POEM 7 ± 2 to post-POEM 1 ± 2, (scale 0–12,
p
< .001), and 92 % of patients achieved treatment success (Eckardt score <4). Two of the three treatment failures in the series occurred in the initial three patients. 15 % of patients had post-POEM symptoms suggestive of gastroesophageal reflux (GerdQ >7). On follow-up HRM, esophagogastric junction integrated relaxation pressure was decreased significantly (pre-POEM 28 ± 12 mmHg vs. post-POEM 11 ± 4 mmHg,
p
< .001), and 47 % of patients studied had partial recovery of peristalsis. On follow-up TBE, barium column heights were decreased compared with preoperatively. Postoperative upper endoscopy revealed esophagitis in 59 % of patients (11 LA Grade A, 2 LA Grade D). However, of the 13 24-h pH monitoring studies performed, only four (31 %) demonstrated pathologic esophageal acid exposure.
Conclusions
In this series, POEM resulted in greater than 90 % symptomatic treatment success at mean 15-month follow-up. Rates of iatrogenic gastroesophageal reflux, as measured both by symptoms and 24-h pH monitoring, appeared to be on par with recent studies of patients undergoing laparoscopic Heller myotomy and pneumatic dilation.
Publisher
Springer US,Springer Nature B.V
Subject
/ Adult
/ Aged
/ Esophageal Achalasia - diagnosis
/ Esophageal Achalasia - physiopathology
/ Esophageal Achalasia - surgery
/ Esophagogastric Junction - physiopathology
/ Esophagogastric Junction - surgery
/ Female
/ Humans
/ Male
/ Medicine
/ Natural Orifice Endoscopic Surgery - methods
/ Postoperative Complications - diagnosis
/ Success
/ Surgery
