Journal Article

MicroRNA‐binding site polymorphisms and risk of colorectal cancer: A systematic review and meta‐analysis

Atlasi, Rasha, Gholami, Morteza, Amoli, Mahsa M., Larijani, Bagher, Hasani‐Ranjbar, Shirin, Taslimi, Reza, Bastami, Milad, Sharifi, Farshad

2019

Overview

Genetic variations in miRNAs binding site might participate in cancer risk. This study aimed to systematically review the association between miRNA‐binding site polymorphisms and colorectal cancer (CRC). Electronic literature search was carried out on PubMed, Web of Science (WOS), Scopus, and Embase. All types of observational studies till 30 November 2018 were included. Overall 85 studies (21 SNPs) from two systematic searches were included analysis. The results showed that in the Middle East population, the minor allele of rs731236 was associated with decreased risk of CRC (heterozygote model: 0.76 [0.61‐0.95]). The minor allele of rs3025039 was related to increased risk of CRC in East Asian population (allelic model: 1.25 [1.01‐1.54]). Results for rs3212986 were significant in overall and subgroup analysis (P < .05). For rs1801157 in subgroup analysis the association was significant in Asian populations (including allelic model: 2.28 [1.11‐4.69]). For rs712, subgroup analysis revealed a significant (allelic model: 1.41 [1.23‐1.61]) and borderline (allelic model: 0.92 [0.84‐1.00]) association in Chinese and Czech populations, respectively. The minor allele of rs17281995 increased risk of CRC in different genetic models (P < .05). Finally, rs5275, rs4648298, and rs61764370 did not show significant associations. In conclusion, minor allele of rs3025039, rs3212986, and rs712 polymorphisms increases the risk of CRC in the East Asian population, and heterozygote model of rs731236 polymorphism shows protective effect in the Middle East population. In Europeans, the minor allele of rs17281995 may increase the risk of CRC, while rs712 may have a protective effect. Further analysis based on population stratifications should be considered in future studies. MicroRNA‐binding site polymorphisms in 3'UTR of target genes could play critical roles on cancer genes regulation by affecting miRNA:mRNA interactions, but no comprehensive study has been considered on association between cancers and the mentioned polymorphisms. In this study, the authors carried out two comprehensive systematic searches and a meta‐analysis on 21 included polymorphisms on colorectal cancer (CRC). The results have shown that these polymorphisms can serve as genetic biomarkers of CRC, and their roles were exclusively related to population stratifications. It is strongly recommended that further studies should be performed to display the effect of population stratifications.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
• Subject: 3' Untranslated Regions - genetics / Alleles / Asia, Eastern - epidemiology / Asian People - genetics / Binding sites / Binding Sites - genetics / Biomarkers / Cancer / Cancer Prevention / Colorectal cancer / Colorectal Neoplasms - epidemiology / Colorectal Neoplasms - genetics / Czech Republic - epidemiology / Ethnicity / Gene Expression Regulation, Neoplastic / Genetic analysis / Genetic diversity / Genetic Predisposition to Disease / Heterozygotes / Humans / Medical prognosis / Meta-analysis / MicroRNAs / MicroRNAs - metabolism / Middle East - epidemiology / miRNA / Observational Studies as Topic / Original Research / Polymorphism / Polymorphism, Single Nucleotide / Population / Population genetics / Risk Factors / Single-nucleotide polymorphism / Studies / Systematic review / Tumors