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Copeptin in anorexia nervosa
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Copeptin in anorexia nervosa
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Journal Article
Copeptin in anorexia nervosa
2020
Overview
Objective Antidiuretic hormone (ADH) is involved in the response to stress and in depression and anxiety. However, studies on ADH in anorexia nervosa (AN) show conflicting results. A major reason for this may be methodological challenges due to short half‐life of ADH in circulation and rapid degradation in vitro. To overcome these obstacles, copeptin, the C‐terminal fragment stemming from the ADH precursor, has been increasingly used as a stable clinical measure for ADH. Furthermore, copeptin has been recognized as a biomarker of insulin resistance in obesity. Methods We measured fasting copeptin in plasma from 25 normohydrated, stable women with AN (BMI 13.0 ± 2.0) and 25 age‐matched women. Results No difference in copeptin levels was found (6.8 ± 1.8 vs. 5.5 ± 0.5 pmol/L). Confirmatory, copeptin concentrations were correlated to insulin resistance assessed by the homeostasis model assessment of insulin resistance. Discussion We report for the first time that copeptin level as a marker of ADH activity is not altered in fluid‐ and electrolyte‐stabilized patients with severe AN patients, indicating that ADH may not be crucial in the pathophysiological involvement of psychologic stress in AN. Antidiuretic hormone (ADH) is involved in response to stress and in depression and anxiety; however, studies in anorexia nervosa (AN) are conflicting, due to short half‐life of ADH in circulation and rapid degradation in vitro. Copeptin has been increasingly used as a stable clinical measure for ADH. We report for the first time that copeptin level is not altered in AN.
