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Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
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Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
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Journal Article
Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
2016
Overview
In carpenter ants, separate behavioral classes, known as castes, are determined by the epigenetic regulation of genes. Simola et al. treated ants of different castes with drugs that affected histone acetylation. Reducing histone acetylation stimulated scouting and foraging behavior. The foraging and scouting behaviors of young ants were permanently changed by directly injecting their brains with histone acetylation inhibitors. Science , this issue p. 10.1126/science.aac6633 Changes in histone acetylation explain differences in the foraging and scouting patterns of different castes of carpenter ants. Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus , morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting behaviors. We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP. Transcriptome and chromatin analysis in brains of scouting minors fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP. Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner. Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Ants
/ Brain
/ Control
/ Forage
/ Forages
/ Genes
/ Histone Deacetylase 2 - antagonists & inhibitors
/ Histone Deacetylase 2 - genetics
/ Histone Deacetylase 2 - physiology
/ Histone Deacetylase Inhibitors - pharmacology
/ Histones
/ Insects
/ Labor
/ Protein Processing, Post-Translational
/ RNA
