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An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
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An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
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Journal Article
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
2020
Overview
Liver cell death has an essential role in nonalcoholic steatohepatitis (NASH). The activity of the energy sensor adenosine monophosphate (AMP)–activated protein kinase (AMPK) is repressed in NASH. Liver-specific AMPK knockout aggravated liver damage in mouse NASH models. AMPK phosphorylated proapoptotic caspase-6 protein to inhibit its activation, keeping hepatocyte apoptosis in check. Suppression of AMPK activity relieved this inhibition, rendering caspase-6 activated in human and mouse NASH. AMPK activation or caspase-6 inhibition, even after the onset of NASH, improved liver damage and fibrosis. Once phosphorylation was decreased, caspase-6 was activated by caspase-3 or -7. Active caspase-6 cleaved Bid to induce cytochrome c release, generating a feedforward loop that leads to hepatocyte death. Thus, the AMPK–caspase-6 axis regulates liver damage in NASH, implicating AMPK and caspase-6 as therapeutic targets.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ AMP
/ AMP-Activated Protein Kinases - genetics
/ AMP-Activated Protein Kinases - metabolism
/ Animals
/ Caspase Inhibitors - pharmacology
/ Caspase Inhibitors - therapeutic use
/ Damage
/ Fibrosis
/ Humans
/ Kinases
/ Liver
/ Mice
/ Non-alcoholic Fatty Liver Disease - drug therapy
/ Non-alcoholic Fatty Liver Disease - enzymology
/ Non-alcoholic Fatty Liver Disease - pathology
/ Proteins
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