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Lineage Tracing Reveals Lgr5+Stem Cell Activity in Mouse Intestinal Adenomas
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Lineage Tracing Reveals Lgr5+Stem Cell Activity in Mouse Intestinal Adenomas
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Journal Article
Lineage Tracing Reveals Lgr5+Stem Cell Activity in Mouse Intestinal Adenomas
2012
Overview
The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains controversial. Studying mouse models, we provide direct, functional evidence for the presence of stem cell activity within primary intestinal adenomas, a precursor to intestinal cancer. By \"lineage retracing\" using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat—containing heterotrimeric guanine nucleotide—binding protein—coupled receptor 5) also marks a subpopulation of adenoma cells that fuel the growth of established intestinal adenomas. These Lgr5 + cells, which represent about 5 to 10% of the cells in the adenomas, generate additional Lgr5 + cells as well as all other adenoma cell types. The Lgr5 + cells are intermingled with Paneth cells near the adenoma base, a pattern reminiscent of the architecture of the normal crypt niche.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Alleles
/ Animal tumors. Experimental tumors
/ Animals
/ Biological and medical sciences
/ Cancer
/ Cell Transformation, Neoplastic
/ color
/ Crypts
/ Datasets
/ Experimental digestive system and abdominal tumors
/ Genes
/ Intestinal Mucosa - metabolism
/ Intestinal Mucosa - pathology
/ Intestinal Neoplasms - genetics
/ Intestinal Neoplasms - pathology
/ Markers
/ Mice
/ Monitors
/ Multipotent Stem Cells - pathology
/ Multipotent Stem Cells - physiology
/ Neoplastic Stem Cells - pathology
/ Neoplastic Stem Cells - physiology
/ Online
/ Receptors, G-Protein-Coupled - analysis
/ Rodents
/ Tumors
