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Associations among stressors across the lifespan, disability, and relapses in adults with multiple sclerosis
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Associations among stressors across the lifespan, disability, and relapses in adults with multiple sclerosis
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Journal Article
Associations among stressors across the lifespan, disability, and relapses in adults with multiple sclerosis
2023
Overview
Introduction
Stress and adversity during childhood, adolescence, and adulthood could impact the present and future health and well‐being of people with multiple sclerosis (PwMS); however, a lifespan approach and nuanced stressor data are scarce in this nascent area of research. Our aim was to examine relationships among comprehensively measured lifetime stressors and two self‐reported MS outcomes: (1) disability and (2) relapse burden changes since COVID‐19 onset.
Methods
Cross‐sectional data were collected from a nationally distributed survey of U.S.‐based adults with MS. Hierarchical block regressions were used to sequentially evaluate contributions to both outcomes independently. Likelihood ratio (LR) tests and Akaike information criterion (AIC) were used to evaluate additional predictive variance and model fit.
Results
A total of 713 participants informed either outcome. Most respondents (84%) were female, 79% had relapsing remitting multiple sclerosis (MS), and mean (SD) age was 49 (12.7) years. Childhood (R2 = .261, p < .001; AIC = 1063, LR p < .05) and adulthood stressors (R2 = .2725, p < .001, AIC = 1051, LR p < .001) contributed significantly to disability, above and beyond prior nested models. Only adulthood stressors (R2 = .0534, p < .001; AIC = 1572, LR p < .01) significantly contributed above the nested model for relapse burden changes since COVID‐19.
Conclusions
Stressors across the lifespan are commonly reported in PwMS and could contribute to disease burden. Incorporating this perspective into the “lived experience with MS” could facilitate personalized health care by addressing key stress‐related exposures and inform intervention research to improve well‐being.
The effect of stressors across the lifespan on Multiple Sclerosis is an under‐researched area. We found that both childhood and adulthood stressors contributed to disability; while only adult stressors contributed to relapse burden since Covid‐19 onset. This study highlights the importance of comprehensively addressing lifetime stressors
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
