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Early Liver Transplantation for Severe Alcoholic Hepatitis
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Journal Article
Early Liver Transplantation for Severe Alcoholic Hepatitis
2011
Overview
Six months of abstinence is typically required before transplantation for alcoholic liver disease. In this study, early liver transplantation improved the 6-month survival rate among selected patients with severe alcoholic hepatitis (77%, vs. 23% without transplantation).
Liver transplantation for alcoholic liver disease has a favorable outcome but remains controversial.
1
,
2
Reluctance to perform transplantation in patients with alcoholism is often based on the view that they are responsible for their illness and are likely to resume alcohol use after transplantation.
3
To select the most appropriate patients with severe forms of alcoholic liver disease for transplantation, most programs require a 6-month abstinence period before patients can be considered. Nevertheless, data regarding the 6-month rule as a predictor of long-term sobriety are controversial.
4
Despite the frequent use of the rule, the United Network for Organ Sharing and the . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Female
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Glucocorticoids - therapeutic use
/ Hepatitis, Alcoholic - drug therapy
/ Hepatitis, Alcoholic - mortality
/ Hepatitis, Alcoholic - surgery
/ Humans
/ Liver, biliary tract, pancreas, portal circulation, spleen
/ Liver. Biliary tract. Portal circulation. Exocrine pancreas
/ Male
/ Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
/ Surgery of the digestive system
/ Survival
