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T-Cadherin and the Ratio of Its Ligands as Predictors of Carotid Atherosclerosis: A Pilot Study

by Balabanenko, Irina , Balatskaya, Maria , Kadrev, Alexey , Samokhodskaya, Larisa , Tkachuk, Vsevolod , Pisaryuk, Alexandra , Kalinina, Natalia , Balatskiy, Alexander , Boytsov, Sergey , Tishuk, Anastasia , Teterina, Marina

in Adiponectin / Arteriosclerosis / Atherosclerosis / Blood pressure / Cadherins / Cardiovascular system / Carotid arteries / Carotid artery / Diabetes / Enzyme-linked immunosorbent assay / Growth factors / high molecular weight adiponectin / Hormones / Hypertension / Hypotheses / Insulin / intima-media thickness / Kinases / Lipoproteins / Low density lipoprotein / Medical research / Metabolism / Molecular weight / Obesity / Plasma / Polymerase chain reaction / Proteins / Single-nucleotide polymorphism / Smooth muscle / T-cadherin / Ultrasonic imaging / Veins & arteries

2021

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T-Cadherin and the Ratio of Its Ligands as Predictors of Carotid Atherosclerosis: A Pilot Study

2021

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T-Cadherin and the Ratio of Its Ligands as Predictors of Carotid Atherosclerosis: A Pilot Study

2021

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Journal Article

T-Cadherin and the Ratio of Its Ligands as Predictors of Carotid Atherosclerosis: A Pilot Study

Balabanenko, Irina,

Balatskaya, Maria,

Kadrev, Alexey,

Samokhodskaya, Larisa,

Tkachuk, Vsevolod,

Pisaryuk, Alexandra,

Kalinina, Natalia,

Balatskiy, Alexander,

Boytsov, Sergey,

Tishuk, Anastasia,

Teterina, Marina

2021

Overview

In the cardiovascular system, atherogenic low-density lipoproteins (LDL) and the protective hormone adiponectin bind to the same receptor, T-cadherin. In this study, we tested the hypothesis that the ratio of circulating LDL to high-molecular weight (HMW) adiponectin could predict the development of atherosclerosis. Using enzyme-linked immunosorbent assay, we measured the level of circulating HMW adiponectin in the blood of donors together with ultrasound measuring of intima-media thickness (IMT) of carotid arteries. Single-nucleotide polymorphisms in the T-cadherin gene were identified using polymerase chain reaction. We found that carotid artery IMT is inversely correlated with the level of HMW in male subjects. We also found that the G allele of rs12444338 SNP in the T-cadherin gene correlates with a lower level of circulating T-cadherin and thinner IMT and therefore could be considered as an atheroprotective genotype. Despite our data, we could not provide direct evidence for the initial study hypothesis. However, we did uncover an important correlation between circulating T-cadherin and thinner carotid IMT.

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Publisher

MDPI AG,MDPI

Subject

/ Cardiovascular system

/ Carotid arteries