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LNK1 and LNK2 Are Transcriptional Coactivators in the Arabidopsis Circadian Oscillator
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LNK1 and LNK2 Are Transcriptional Coactivators in the Arabidopsis Circadian Oscillator
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Journal Article
LNK1 and LNK2 Are Transcriptional Coactivators in the Arabidopsis Circadian Oscillator
2014
Overview
Transcriptional feedback loops are central to the architecture of eukaryotic circadian clocks. Models of the Arabidopsis thaliana circadian clock have emphasized transcriptional repressore, but recently, Myb-like REVEILLE (RVE) transcription factors have been established as transcriptional activators of central clock components, including PSEUDO-RESPONSE REGULATORS (PRR5) and TIMING OF CAB EXPRESSION1 (TOC1). We show here that NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATEDI (LNK1) and LNK2, members of a small family of four LNK proteins, dynamically interact with morningexpressed oscillator components, including RVE4 and RVE8. Mutational disruption of LNK1 and LNK2 function prevents transcriptional activation of PRR5 by RVE8. The LNKs lack known DNA binding domains, yet LNK1 acts as a transcriptional activator in yeast and in planta. Chromatin immunoprecipitation shows that LNK1 is recruited to the PRR5 and TOC1 promoters in planta. We conclude that LNK1 is a transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1 through recruitment to their promoters via interaction with bona fide DNA binding proteins such as RVE4 and RVE8.
Publisher
American Society of Plant Biologists
Subject
/ Arabidopsis - radiation effects
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Chromatin Immunoprecipitation
/ DNA
/ Gene Expression Regulation, Plant - radiation effects
/ Genes
/ Light
/ Mutation
/ Plants
/ Promoter Regions, Genetic - genetics
/ Trans-Activators - metabolism
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ Yeasts
