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Various modes of action of dietary phytochemicals, sulforaphane and phenethyl isothiocyanate, on pathogenic bacteria
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Various modes of action of dietary phytochemicals, sulforaphane and phenethyl isothiocyanate, on pathogenic bacteria
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Journal Article
Various modes of action of dietary phytochemicals, sulforaphane and phenethyl isothiocyanate, on pathogenic bacteria
2019
Overview
Isothiocyanates (ITCs) derived from cruciferous plants reveal antibacterial activity, although detailed mechanism is not fully elucidated. Recently it has been reported that ITCs induce the stringent response in
Escherichia coli
strains. The aim of this work was to determine whether two isothiocyanates, sulforaphane (SFN) and phenethyl isothiocyanate (PEITC), similarly as in
E
.
coli
induce stringent response in
Bacillus subtilis
, model Gram(+) bacterium, and test their potency against a panel of clinical isolates belonging to Gram(+) or Gram(−) groups. Minimal inhibitory concentrations were determined as well as effect of ITCs on membranes integrity, synthesis of DNA, RNA and stringent response alarmones was assessed. SFN and PEITC are effective against
B
.
subtilis
and bacterial isolates, namely
E
.
coli
,
K
.
pneumonia
,
S
.
aureus
,
S
.
epidermidis
and
E
.
faecalis
. Interestingly, in
B
.
subtilis
and
E
.
faecalis
the inhibition of growth and nucleic acids synthesis is independent of ppGpp accumulation. In bacteria, which do not induce the stringent response in the presence of ITCs, membrane integrity disruption is observed. Thus, ITCs are effective against different pathogenic bacteria and act by at least two mechanisms depending on bacteria species.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 14
/ 14/34
/ 14/63
/ 38
/ 38/71
/ 64
/ 82
/ 96
/ Bacillus subtilis - drug effects
/ Bacteria
/ E coli
/ Escherichia coli - drug effects
/ Humanities and Social Sciences
/ Isothiocyanates - pharmacology
/ Klebsiella pneumoniae - drug effects
/ Phytochemicals - pharmacology
/ RNA
/ Science
