Asset Details
Do you wish to reserve the book?
Corneal nerve alterations in acute Acanthamoeba and fungal keratitis: an in vivo confocal microscopy study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Corneal nerve alterations in acute Acanthamoeba and fungal keratitis: an in vivo confocal microscopy study
Do you wish to request the book?
Corneal nerve alterations in acute Acanthamoeba and fungal keratitis: an in vivo confocal microscopy study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Corneal nerve alterations in acute Acanthamoeba and fungal keratitis: an in vivo confocal microscopy study
2012
Overview
Purpose
To study sub-basal corneal nerve alterations in patients with acute
Acanthamoeba
keratitis (AK) and fungal keratitis (FK), using laser
in vivo
confocal microscopy (IVCM).
Methods
A retrospective analysis of IVCM (Heidelberg Retina Tomograph 3/Rostock Cornea Module) images of 10 AK corneas and 4 FK corneas was performed, and the results compared with those of 10 normal and 12 acute herpetic keratitis (HK) corneas. Sub-basal corneal nerves were analyzed with respect to total number of nerves, main nerve trunks, branching pattern and total length of nerves per image, as well as tortuosity. For each variable, results for three frames were averaged and analyzed using analysis of variance.
Results
Total corneal nerve length was significantly (
P
<0.0001) reduced in patients with AK (193.4±124.5
μ
m) and FK (268.6±257.4
μ
m) when compared with normal controls (3811.84±911.4
μ
m). Total nerve counts in patients with AK (3.9±1.2) and FK (3.6±3.2) were significantly (
P
<0.0001) decreased in comparison with normal controls (24.7±5.5). The number of main nerve trunks and nerve branching was found to be significantly lower in AK and FK corneas, when compared with controls. There was a statistically significant decrease in the above parameters when compared with HK controls.
Conclusions
The sub-basal corneal nerve plexus is significantly diminished in eyes with AK and FK, as demonstrated by IVCM. These results are more profound than previously reported findings of a diminished nerve plexus in HK.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Acanthamoeba Keratitis - pathology
/ Adult
/ Biological and medical sciences
/ Cornea
/ Diseases of cornea, anterior segment and sclera
/ Eye
/ Eye Infections, Fungal - pathology
/ Female
/ Humans
/ Lasers
/ Male
/ Medicine
/ Microscopy, Confocal - methods
/ Nerves
/ Ophthalmic Nerve - pathology
/ Pharmaceutical Sciences/Technology
/ Retina
/ Surgery
