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In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum
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In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum
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Journal Article
In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum
2018
Overview
The
Plasmodium falciparum
variant surface antigen PfEMP1 expressed on the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the
var
genes encoding PfEMP1 expands there are opportunities, despite the high degree of sequence diversity demonstrated by this gene family, to reconstruct full-length
var
genes from small sequence tags generated from patient isolates. To test whether this is possible we have used a set of recently laboratory adapted ICAM-1-binding parasite isolates to generate sequence tags and, from these, to identify the full-length PfEMP1 being expressed by them. In a subset of the strains available we were able to produce validated, full-length
var
gene sequences and use these to conduct biophysical analyses of the ICAM-1 binding regions.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 9/10
/ Amino Acid Sequence - genetics
/ Animals
/ Antigens, Surface - genetics
/ Genes
/ Humanities and Social Sciences
/ Humans
/ Intercellular adhesion molecule 1
/ Intercellular Adhesion Molecule-1 - genetics
/ Malaria
/ Malaria, Falciparum - genetics
/ Malaria, Falciparum - parasitology
/ Plasmodium falciparum - genetics
/ Plasmodium falciparum - pathogenicity
/ Protozoan Proteins - chemistry
/ Protozoan Proteins - genetics
/ Science
/ Var gene
