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Structured line illumination Raman microscopy
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Journal Article
Structured line illumination Raman microscopy
2015
Overview
In the last couple of decades, the spatial resolution in optical microscopy has increased to unprecedented levels by exploiting the fluorescence properties of the probe. At about the same time, Raman imaging techniques have emerged as a way to image inherent chemical information in a sample without using fluorescent probes. However, in many applications, the achievable resolution is limited to about half the wavelength of excitation light. Here we report the use of structured illumination to increase the spatial resolution of label-free spontaneous Raman microscopy, generating highly detailed spatial contrast from the ensemble of molecular information in the sample. Using structured line illumination in slit-scanning Raman microscopy, we demonstrate a marked improvement in spatial resolution and show the applicability to a range of samples, including both biological and inorganic chemical component mapping. This technique is expected to contribute towards greater understanding of chemical component distributions in organic and inorganic materials.
Raman imaging provides visualization of molecular content in a sample, but has been practically limited in resolution. Here, the authors implement structured line illumination in slit-scanning Raman microscopy, expanding its resolvable spatial frequencies without spoiling the advantage of the Raman approach.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
