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Oxylipins produced by Pseudomonas aeruginosa promote biofilm formation and virulence
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Oxylipins produced by Pseudomonas aeruginosa promote biofilm formation and virulence
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Journal Article
Oxylipins produced by Pseudomonas aeruginosa promote biofilm formation and virulence
2016
Overview
The oxygenation of unsaturated fatty acids by dioxygenases occurs in all kingdoms of life and produces physiologically important lipids called oxylipins. The biological roles of oxylipins have been extensively studied in animals, plants, algae and fungi, but remain largely unidentified in prokaryotes. The bacterium
Pseudomonas aeruginosa
displays a diol synthase activity that transforms several monounsaturated fatty acids into mono- and di-hydroxylated derivatives. Here we show that oxylipins derived from this activity inhibit flagellum-driven motility and upregulate type IV pilus-dependent twitching motility of
P. aeruginosa.
Consequently, these oxylipins promote bacterial organization in microcolonies, increasing the ability of
P. aeruginosa
to form biofilms
in vitro
and
in vivo
(in
Drosophila
flies). We also demonstrate that oxylipins produced by
P. aeruginosa
promote virulence in
Drosophila
flies and lettuce. Our study thus uncovers a role for prokaryotic oxylipins in the physiology and pathogenicity of bacteria.
Oxygenated fatty acids known as oxylipins play important roles in mammals, plants and fungi. Here, the authors show that oxylipins, produced by the pathogenic bacterium
Pseudomonas aeruginosa
, promote biofilm formation and virulence.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
