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Reduced expression of central innate defense molecules in pancreatic biopsies from subjects with Type 1 diabetes
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Reduced expression of central innate defense molecules in pancreatic biopsies from subjects with Type 1 diabetes
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Journal Article
Reduced expression of central innate defense molecules in pancreatic biopsies from subjects with Type 1 diabetes
2024
Overview
Aims/Hypothesis
Defensins play a crucial role in the innate immune system's first defense against microbial threats. However, little is known about the defensin system in the pancreas, especially in relation to Type 1 diabetes. We explore the expression of defensins in different disease stages of Type 1 diabetes and correlated obtained findings to the degree of inflammation, providing new insights into the disease and the innate immune system.
Material and methods
Pancreases from non-diabetic human organ donors of different age groups and donors with Type 1 diabetes with different disease duration were examined. Sections from head, body and tail of the pancreas were stained for eight different defensins and for immune cells; CD3+, CD45+, CD68+ and NES+ (granulocytes).
Results
In non-diabetic adult controls the level of expression for defensins Beta-1,Alpha-1, Cathelicidin and REG3A correlated with the level of inflammation. In contrast, individuals with Type 1 diabetes exhibit a reduction or absence of several central defensins regardless of the level of inflammation in their pancreas. The expression of Cathelicidin is present in neutrophils and macrophages but not in T-cells in subjects with Type 1 diabetes.
Conclusions
Obtained findings suggest a pancreatic dysfunction in the innate immune system and the bridging to the adaptive system in Type 1 diabetes. Further studies on the role of the local innate immune system in Type 1 diabetes is needed.
Publisher
Springer Milan,Springer Nature B.V
Subject
/ Adult
/ alpha-Defensins - metabolism
/ Antigens, Differentiation, Myelomonocytic - metabolism
/ Antimicrobial Cationic Peptides - metabolism
/ Bacteria
/ Biologi med inriktning mot molekylär immunologi
/ Biology with specialization in Molecular Immunology
/ Biopsy
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - immunology
/ Diabetes Mellitus, Type 1 - metabolism
/ Diabetes Mellitus, Type 1 - pathology
/ Female
/ Humans
/ Male
/ Medicine
/ Original
/ Pancreas
/ Spleen
