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A Novel Method to Compute the Contact Surface Area Between an Organ and Cancer Tissue
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A Novel Method to Compute the Contact Surface Area Between an Organ and Cancer Tissue
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A Novel Method to Compute the Contact Surface Area Between an Organ and Cancer Tissue
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Journal Article
A Novel Method to Compute the Contact Surface Area Between an Organ and Cancer Tissue
2025
Overview
The contact surface area (CSA) quantifies the interface between a tumor and an organ and is a key predictor of perioperative outcomes in kidney cancer. However, existing CSA computation methods rely on shape assumptions and manual annotation. We propose a novel approach using 3D reconstructions from computed tomography (CT) scans to provide an accurate CSA estimate. Our method includes a segmentation protocol and an algorithm that processes reconstructed meshes. We also provide an open-source implementation with a graphical user interface. Tested on synthetic data, the algorithm showed minimal error and was evaluated on data from 82 patients. We computed the CSA using both our approach and Hsieh’s method, which relies on subjective CT scan measurements, in a double-blind study with two radiologists of different experience levels. We assessed the correlation between our approach and the expert radiologist’s measurements, as well as the deviation of both our method and the less experienced radiologist from the expert’s values. While the mean and variance of the differences between the less experienced radiologist and the expert were lower, our method exhibited a slight deviation from the expert’s, demonstrating its reliability and consistency. These findings are further supported by the results obtained from synthetic data testing.
