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Infant’s engagement and emotion as predictors of autism or intellectual disability in West syndrome
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Infant’s engagement and emotion as predictors of autism or intellectual disability in West syndrome
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Journal Article
Infant’s engagement and emotion as predictors of autism or intellectual disability in West syndrome
2014
Overview
West syndrome (WS) is a rare epileptic encephalopathy with early onset and a high risk of autistic outcome. The
PréAut
grid assesses this risk following WS onset by taking into account synchrony and emotion in interactions and by evaluating the baby’s active desire to engage in pleasant interactions (especially the infant’s early active behaviors that encourage being gazed at or kissed by the mother or to share joy with her). We followed a sample of 25 WS patients prospectively from disease onset and assessed whether the
PréAut
grid before 9 months, and the checklist for autism in toddlers (CHAT) at 18 and 24 months predicted autism or intellectual disability (ID) outcomes at 4 years. We found that the
PréAut
grid at 9 months (sensitivity = 0.83; specificity = 1) had similar prediction parameters as the CHAT at 18 months (sensitivity = 0.90; specificity = 0.83) and 24 months (sensitivity = 0.92; specificity = 1). WS patients with a positive
PréAut
screening at 9 months had a risk of having autism or ID at 4 years, which is 38 times that of children with a negative
PréAut
grid [OR = 38.6 (95 % CI 2.2–2961);
p
= 0.006]. We conclude that the
PréAut
grid could be a useful tool for the early detection of autism or ID risk in the context of WS. Further research is needed to assess the
PréAut
grid in other contexts (e.g. infants at high-risk for non-syndromic autism).
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V,Springer Verlag (Germany),Dr. Dietrich Steinkopff Verlag
Subject
Adult and adolescent clinical studies
/ Autism
/ Autistic Disorder - diagnosis
/ Biological and medical sciences
/ Chat
/ Child and Adolescent Psychiatry
/ Computer Vision and Pattern Recognition
/ Emotions
/ Female
/ Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
/ Humans
/ Infant
/ Infants
/ Male
/ Medicine
/ Mothers
/ Nervous system (semeiology, syndromes)
/ Outcome and Process Assessment (Health Care)
/ Patients
/ Psychology. Psychoanalysis. Psychiatry
/ Risk
/ Robotics
/ Sciences de la santé humaine
/ Spasms, Infantile - diagnosis
/ Toddlers
