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Modulation of lncRNA H19 enhances resveratrol‐inhibited cancer cell proliferation and migration by regulating endoplasmic reticulum stress

by Zhao, Qi , Zhou, Kunpeng , Li, Chunting , Cheng, Linglin , Zhang, Xinyue , Li, Yanlin , Li, Tianye , Wu, Zihan , Luo, Yingqi , Huang, Yongye

in Antibodies / Apoptosis / Autophagy / Cancer / Cancer therapies / Cell cycle / Cell death / Cell growth / Cell Line, Tumor / Cell migration / Cell proliferation / Cell Proliferation - genetics / Cell survival / Chemotherapy / Cloning / Endoplasmic reticulum / Endoplasmic Reticulum Stress - drug effects / ER stress / Gastric cancer / Gene expression / Humans / Laboratory animals / lncRNA / Medical prognosis / Metastasis / Neoplasms - drug therapy / Neoplasms - pathology / Non-coding RNA / Original / Proteins / Resveratrol / Resveratrol - pharmacology / RNA, Long Noncoding - genetics / RNA, Long Noncoding - metabolism / Signal transduction / Thapsigargin / Tumors / Tunicamycin

2022

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Modulation of lncRNA H19 enhances resveratrol‐inhibited cancer cell proliferation and migration by regulating endoplasmic reticulum stress

by Zhao, Qi , Zhou, Kunpeng , Li, Chunting , Cheng, Linglin , Zhang, Xinyue , Li, Yanlin , Li, Tianye , Wu, Zihan , Luo, Yingqi , Huang, Yongye

2022

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Modulation of lncRNA H19 enhances resveratrol‐inhibited cancer cell proliferation and migration by regulating endoplasmic reticulum stress

by Zhao, Qi , Zhou, Kunpeng , Li, Chunting , Cheng, Linglin , Zhang, Xinyue , Li, Yanlin , Li, Tianye , Wu, Zihan , Luo, Yingqi , Huang, Yongye

2022

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Journal Article

Modulation of lncRNA H19 enhances resveratrol‐inhibited cancer cell proliferation and migration by regulating endoplasmic reticulum stress

Zhao, Qi,

Zhou, Kunpeng,

Li, Chunting,

Cheng, Linglin,

Zhang, Xinyue,

Li, Yanlin,

Li, Tianye,

Wu, Zihan,

Luo, Yingqi,

Huang, Yongye

2022

Overview

The phytoalexin resveratrol exhibits anti‐tumour activity in many types of cancer. In this study, we showed that resveratrol suppressed the survival of gastric tumour cells both in vivo and in vitro. Resveratrol promoted apoptosis, autophagy and endoplasmic reticulum (ER) stress in a dose‐dependent manner. RNA‐seq analysis showed that multiple cell death signalling pathways were activated after resveratrol treatment, while the use of ER stress activators (tunicamycin and thapsigargin) in combinatorial with resveratrol led to further inhibition of cancer cell survival. Results also showed that resveratrol altered the expression of several long non‐coding RNAs (lncRNAs), including MEG3, PTTG3P, GAS5, BISPR, MALAT1 and H19. Knockdown of H19 in resveratrol‐treated cells further enhanced the effects of resveratrol on apoptosis, ER stress and cell cycle S‐phase arrest. Furthermore, the migratory ability of resveratrol‐treated cells was dramatically decreased after H19 knockdown. In conclusion, resveratrol inhibited cancer cell survival, while knockdown of lncRNA H19 resulted in increased sensitivity to resveratrol therapy.

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Publisher

John Wiley & Sons, Inc,John Wiley and Sons Inc

Subject

/ Cancer