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Would Colloidal Gold Nanocarriers Present An Effective Diagnosis Or Treatment For Ischemic Stroke?
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Journal Article
Would Colloidal Gold Nanocarriers Present An Effective Diagnosis Or Treatment For Ischemic Stroke?
2019
Overview
This study was conducted to evaluate OX26-PEG-coated gold nanoparticles (GNPs) (OX26@GNPs) as a novel targeted nanoparticulate system on cell survival after ischemic stroke.
Dynamic light scattering (DLS), zeta sizer, and transmission electron microscopy (TEM) were performed to characterize the OX26@GNPs. The effect of OX26@GNPs on infarct volume, neuronal loss, and necroptosis was evaluated 24 h after reperfusion using 2, 3,5-Triphenyltetrazolium chloride (TTC) staining, Nissl staining and Western blot assay, respectively.
Conjugation of OX26-PEG to the surface of the 25 nm colloidal gold particles increased their size to 32±2 nm, while a zeta potential change of -40.4 to 3.40 mV remarkably increased the stability of the nanoparticles. Most importantly, OX26@GNPs significantly increased the infarcted brain tissue, while bare GNPs and PEGylated GNPs had no effect on the infarct volume. However, our results indicated an extension of necroptotic cell death, followed by cell membrane damage.
Collectively, our results showed that the presently formulated OX26@GNPs are not suitable nanocarriers nor contrast agents under oxidative stress for the diagnosis and treatment of ischemic stroke. Moreover, our findings suggest that the cytotoxicity of GNPs in the brain is significantly associated with their surface charge.
Publisher
Dove Medical Press Limited,Dove,Dove Medical Press
Subject
/ Antibodies, Monoclonal - metabolism
/ Brain Ischemia - cerebrospinal fluid
/ Brain Ischemia - complications
/ Gold
/ Gold Colloid - administration & dosage
/ Humans
/ Ischemia
/ Male
/ Metal Nanoparticles - administration & dosage
/ Metal Nanoparticles - chemistry
/ Metal Nanoparticles - toxicity
/ Metal Nanoparticles - ultrastructure
/ Neurons
/ Novels
/ Oxidative Stress - drug effects
/ Stroke
