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Analysis of clonality and antibiotic resistance among early clinical isolates of enterococcus faecium in the United States
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Analysis of clonality and antibiotic resistance among early clinical isolates of enterococcus faecium in the United States
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Analysis of clonality and antibiotic resistance among early clinical isolates of enterococcus faecium in the United States
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Journal Article
Analysis of clonality and antibiotic resistance among early clinical isolates of enterococcus faecium in the United States
2009
Overview
Background: The Enterococcus faecium genogroup, referred to as clonal complex 17 (CC17), seems to possess multiple determinants that increase its ability to survive and cause disease in nosocomial environments. Methods: Using 53 clinical and geographically diverse US E. faecium isolates dating from 1971 to 1994, we determined the multilocus sequence type; the presence of 16 putative virulence genes (hyl Efm, esp Efm, and fms genes); resistance to ampicillin (AMP) and vancomycin (VAN); and high-level resistance to gentamicin and streptomycin. Results: Overall, 16 different sequence types (STs), mostly CC17 isolates, were identified in 9 different regions of the United States. The earliest CC17 isolates were part of an outbreak that occurred in 1982 in Richmond, Virginia. The characteristics of CC17 isolates included increases in resistance to AMP, the presence of hyl Efm and esp Efm, emergence of resistance to VAN, and the presence of at least 13 of 14 fms genes. Eight of 41 of the early isolates with resistance to AMP, however, were not in CC17. Conclusions: Although not all early US AMP isolates were clonally related, E. faecium CC17 isolates have been circulating in the United States since at least 1982 and appear to have progressively acquired additional virulence and antibiotic resistance determinants, perhaps explaining the recent success of this species in the hospital environment.
Publisher
Journal of Infectious Diseases,Infectious Diseases Society of America,The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Ampicillin Resistance - genetics
/ BACTERIA
/ Biological and medical sciences
/ Cross Infection - microbiology
/ Drug Resistance, Multiple, Bacterial - genetics
/ Enterococcus faecium - drug effects
/ Enterococcus faecium - genetics
/ Fundamental and applied biological sciences. Psychology
/ Gram-Positive Bacterial Infections
/ Humans
