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Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents
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Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents
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Journal Article
Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents
2023
Overview
Despite the growing interest by researchers into cellular senescence, a hallmark of cellular aging, its role in human skin remains equivocal. The skin is the largest and most accessible human organ, reacting to the external and internal environment. Hence, it is an organ of choice to investigate cellular senescence and to target root‐cause aging processes using senolytic and senomorphic agents, including naturally occurring plant‐based derivatives. This review presents different aspects of skin cellular senescence, from physiology to pathology and signaling pathways. Cellular senescence can have both beneficial and detrimental effects on the skin, indicating that both prosenescent and antisenescent therapies may be desirable, based on the context. Knowledge of molecular mechanisms involved in skin cellular senescence may provide meaningful insights for developing effective therapeutics for senescence‐related skin disorders, such as wound healing and cosmetic skin aging changes. Aging and external stressors including exposure to UV light promote senescence of keratinocytes accelerating aging process. Development of effective plant‐based senotherapeutics represent novel approaches for senescent‐related skin disorders and can be used in cosmetic skin changes related to aging.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
