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Two Randomized Trials of Linaclotide for Chronic Constipation

by MacDougall, James E , Jia, Xinwei D , Fitch, Donald A , Jeglinski, Brenda I , Schneier, Harvey A , Shiff, Steven J , Fox, Susan M , Eng, Paul , Kurtz, Caroline B , Shao, James Z , Johnston, Jeffrey M , Lavins, Bernard J , Currie, Mark G , Lembo, Anthony J

in Abdomen / Adolescent / Adult / Aged / Aged, 80 and over / Biological and medical sciences / Chronic Disease / Clinical trials / Constipation / Constipation - drug therapy / Defecation - drug effects / Diarrhea / Diarrhea - chemically induced / Double-Blind Method / Evidence-based medicine / Female / Gastroenterology. Liver. Pancreas. Abdomen / General aspects / Guanylate Cyclase / Humans / Intestine / Laboratories / Laxatives / Laxatives - adverse effects / Laxatives - therapeutic use / Male / Medical sciences / Middle Aged / Other diseases. Semiology / Patients / Peptides / Peptides - adverse effects / Peptides - therapeutic use / Pharmaceuticals / Quality of Life / Receptors, Guanylate Cyclase-Coupled - agonists / Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / Withholding Treatment / Young Adult

2011

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Two Randomized Trials of Linaclotide for Chronic Constipation

2011

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Two Randomized Trials of Linaclotide for Chronic Constipation

2011

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Journal Article

Two Randomized Trials of Linaclotide for Chronic Constipation

MacDougall, James E,

Jia, Xinwei D,

Fitch, Donald A,

Jeglinski, Brenda I,

Schneier, Harvey A,

Shiff, Steven J,

Fox, Susan M,

Eng, Paul,

Kurtz, Caroline B,

Shao, James Z,

Johnston, Jeffrey M,

Lavins, Bernard J,

Currie, Mark G,

Lembo, Anthony J

2011

Overview

In two 12-week trials, linaclotide, a minimally absorbed peptide agonist of the guanylate cyclase-C receptor, increased the frequency of spontaneous bowel movements and improved symptoms in patients with chronic constipation. Longer-term studies are needed. Chronic constipation affects between 12 and 19% of the U.S. population. 1 , 2 The symptoms of chronic constipation, including infrequent bowel movements, hard stools, straining during defecation, bloating, abdominal discomfort, and a sense of incomplete evacuation, 3 adversely affect quality of life 4 , 5 and are associated with substantial costs. 6 , 7 Few currently available therapies for chronic constipation have been shown to be effective and safe in well-controlled, long-term trials, 8 and many persons with this disorder are not completely satisfied with their current treatment options. 4 Linaclotide is a 14-amino-acid synthetic peptide that is structurally related to the endogenous guanylin peptide family. It binds . . .

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Publisher

Massachusetts Medical Society

Subject

Abdomen

/ Adolescent

/ Adult

/ Aged

/ Aged, 80 and over

/ Biological and medical sciences

/ Chronic Disease