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Less-Tight versus Tight Control of Hypertension in Pregnancy
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Journal Article
Less-Tight versus Tight Control of Hypertension in Pregnancy
2015
Overview
In this trial comparing less-tight control of hypertension (target diastolic blood pressure, 100 mm Hg) with tight control (85 mm Hg) among pregnant women, rates of pregnancy loss, high-level neonatal care, and serious maternal complications were similar between groups.
Almost 10% of pregnant women have hypertension; hypertension is preexisting in 1%, gestational hypertension without proteinuria develops in 5 to 6%, and preeclampsia develops in 2%.
1
Preexisting hypertension and gestational hypertension before 34 weeks are associated with an increased risk of perinatal and maternal complications.
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–
4
Blood-pressure targets for women with nonsevere hypertension during pregnancy are much debated. Relevant randomized, controlled trials have been small and of moderate or poor quality; tight control (the use of antihypertensive therapy to normalize blood pressure) has been associated with maternal benefits (e.g., a decrease in the frequency of severe hypertension and possibly in . . .
Publisher
Massachusetts Medical Society
Subject
Abortion, Spontaneous - etiology
/ Adult
/ Antihypertensive Agents - administration & dosage
/ Blood Pressure - drug effects
/ Female
/ Fetuses
/ Humans
/ Hypertension, Pregnancy-Induced - drug therapy
/ Intensive Care, Neonatal - statistics & numerical data
/ Neonates
/ Pregnancy Complications - epidemiology
/ Pregnancy Complications - etiology
/ Proteins
