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Gentamicin–Collagen Sponge for Infection Prophylaxis in Colorectal Surgery
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Gentamicin–Collagen Sponge for Infection Prophylaxis in Colorectal Surgery
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Journal Article
Gentamicin–Collagen Sponge for Infection Prophylaxis in Colorectal Surgery
2010
Overview
The gentamicin–collagen sponge is used outside the U.S. to prevent surgical-site infection. In this trial of patients undergoing colorectal surgery, patients who had such sponges inserted above the fascia had higher, not lower, rates of infection.
Postoperative surgical-site infection continues to be a significant problem after general surgical procedures, especially colorectal surgery. Reported incidences of surgical-site infection among patients who undergo colorectal surgery range from 8.2%
1
to 26%,
2
with an incidence of approximately 18 to 20% in most series.
3
–
7
Postoperative surgical-site infection is associated with a significant rate of complications and cost.
8
–
10
Thus, prevention of these frequent infections has been the focus of numerous strategies.
2
–
7
,
11
The gentamicin–collagen sponge was developed to prevent and treat wound infections by providing high gentamicin concentrations locally, avoiding the high systemic concentrations associated with nephrotoxicity. The sponge's . . .
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Anti-Bacterial Agents - administration & dosage
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Biological and medical sciences
/ Collagen
/ Colorectal Neoplasms - surgery
/ Female
/ Gentamicins - administration & dosage
/ Humans
/ Male
/ Pharmacology. Drug treatments
/ Surgery
/ Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
/ Surgery of the digestive system
/ Surgical Sponges - adverse effects
