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Immunity for tumors and microbes after autotransplantation: if you build it, they will (not) come
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Immunity for tumors and microbes after autotransplantation: if you build it, they will (not) come
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Journal Article
Immunity for tumors and microbes after autotransplantation: if you build it, they will (not) come
2006
Overview
Relapses after autologous stem cell transplants for hematopoietic malignancies are frequent and post-transplant infections continue to cause significant post-transplant morbidity and even mortality. The post-transplant period is typically characterized by low lymphocyte counts and impaired immune cell function. Early restoration of immune function may contribute to better disease control and enhance protection from infections. Indeed the attainment of a ‘minimal residual disease’ status following high-dose therapy makes the early post-transplant period ideal for the introduction of antitumor immunotherapy. Attempts to generate immunity against tumor and microbial antigens after autotransplantation have included vaccinations, T cell infusions (both resting and activated) and combinations of vaccinations and adoptive T cell infusions. One successful strategy for generating robust immune responses against microbial antigens was the combination of pre and post-transplant immunizations along with an early (post-transplant) infusion of
in vivo
vaccine-primed and
ex vivo
co-stimulated autologous T cells. Whether this or similar strategies will lead to the generation of effective antitumor immunity is unknown. The lessons gained from efforts to rebuild immune system function in the setting of autotransplantation may also be applicable to the problem of restoring immunity in other immunodeficient groups such as patients with cancer or HIV disease and the elderly.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
/ Antigens
/ Bacterial Infections - etiology
/ Bacterial Infections - immunology
/ Bacterial Infections - prevention & control
/ Bacterial Vaccines - administration & dosage
/ Bacterial Vaccines - immunology
/ Biological and medical sciences
/ Bone marrow, stem cells transplantation. Graft versus host reaction
/ Cancer Vaccines - administration & dosage
/ Cancer Vaccines - immunology
/ HIV
/ Human immunodeficiency virus
/ Humans
/ Immunity
/ Immunotherapy, Adoptive - methods
/ Medicine
/ review
/ Stem Cell Transplantation - methods
/ T-Lymphocytes - transplantation
/ Transfusions. Complications. Transfusion reactions. Cell and gene therapy
/ Tumors
/ Vaccines
