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Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
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Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
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Journal Article
Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
2009
Overview
CCAAT/enhancer binding protein alpha (
CEBPA)
mutations in AML are associated with favourable prognosis and are divided into N- and C-terminal mutations. The majority of AML patients have both types of mutations. We assessed the prognostic significance of single (
n
=7) and double (
n
=12)
CEBPA
mutations among 224 AML patients. Double
CEBPA
mutations conferred a decisively favourable overall (
P
=0.006) and disease-free survival (
P
=0.013). However, clinical outcome of patients with single
CEBPA
mutations was not different from CEBPA wild-type patients. In a multivariable analysis, only double – but not single –
CEBPA
mutations were identified as independent prognostic factors. These findings indicate heterogeneity within AML patients with
CEBPA
mutations.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
Biological and medical sciences
/ Biomedical and Life Sciences
/ CCAAT-Enhancer-Binding Proteins - blood
/ CCAAT-Enhancer-Binding Proteins - genetics
/ Hematologic and hematopoietic diseases
/ Humans
/ Leukemia, Myeloid, Acute - blood
/ Leukemia, Myeloid, Acute - genetics
/ Leukemia, Myeloid, Acute - mortality
/ Leukemia, Myeloid, Acute - pathology
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Mutation
/ Oncology
/ Peptides
/ Proteins
/ Tumors
