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Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis
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Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis
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Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis
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Journal Article
Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis
2017
Overview
Autophagosomal membranes are emerging as platforms for various cell survival and death signaling networks beyond autophagy. While autophagy-dependent cell death has been reported in response to a variety of stimuli, the underlying molecular mechanisms remain far from clear. Here, we demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intracellular death-inducing signaling complex (iDISC). Importantly, iDISC-induced caspase-8 dimerization and activation occurs on accumulated autophagosomal membranes and requires the LC3 conjugation machinery but is independent from the extrinsic pathway of apoptosis. Moreover, we have identified NF-κB signaling and c-FLIP as negative regulators of iDISC-mediated caspase-8 activation and apoptosis. Collectively, these findings reveal autophagosomal membrane completion as a novel target to switch cytoprotective autophagy to apoptosis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/31
/ 14/1
/ 14/19
/ 14/28
/ 14/32
/ 14/35
/ 14/63
/ 38/89
/ 42/35
/ Autophagy-Related Proteins - deficiency
/ Autophagy-Related Proteins - genetics
/ Autophagy-Related Proteins - metabolism
/ Biomedical and Life Sciences
/ CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism
/ Caspase
/ Humans
/ Vesicular Transport Proteins - deficiency
