Journal Article

Effects of oral administration of Bifidobacterium animalis subsp. lactis HN019 on the treatment of plaque-induced generalized gingivitis

Júnior, Mario Taba, Silva, Giselle Aparecida, Palioto, Daniela Bazan, Messora, Michel Reis, Ribeiro, Marcella Costa, Casarin, Renato, Silva, Pedro Henrique Félix, de Souza, Sérgio Luís Scombatti, Honório, Heitor Marques, de Almeida Silva Levi, Yara Loyanne, Furlaneto, Flávia Aparecida Chaves, de Souza Salvador, Sergio Luiz, Júnior, Arthur Belem Novaes

2023

Overview

ObjectivesThis double-blind, randomized, placebo-controlled clinical trial evaluated the adjuvant effects of Bifidobacterium lactis HN019 on the treatment of plaque-induced generalized gingivitis.Materials and methodsSixty patients were submitted to professional supragingival scaling and prophylaxis. They were randomly assigned to test (probiotic lozenges containing B. lactis HN019, n = 30) or control (placebo lozenges, n = 30) groups. Lozenges were consumed twice a day for 8 weeks. Bleeding on probing (BoP), Gingival Index (GI), Plaque Index (PI), probing depth (PD), and clinical attachment level (CAL) were evaluated at baseline and after 2 and 8 weeks. Gingival crevicular fluid (GCF) was collected at baseline and at 8 weeks for analysis of the inflammatory mediators IL-1β, IL-1α, IL-8, MCP-1, and MIP-1β. Data were statistically analyzed (p < 0.05).ResultsAfter 8 weeks, both groups showed reduction in the percentage of PI, with no significant difference between groups (p = 0.7423). The test group presented a lower percentage of BoP and a higher percentage of sites with GI ≤ 1 when compared with the control group at the end of the study (p < 0.0001). At 8 weeks, the test group had a greater number of patients without generalized gingivitis than the control group (20 and 11 patients, respectively; p < 0.05). The test group presented significantly lower levels of IL-1α, IL-1β, and MCP-1 in GCF than the control group at the end of the study (p < 0.05).ConclusionThe adjunct use of B. lactis HN019 promotes additional clinical and immunological benefits in the treatment of generalized gingivitis.Clinical relevanceB. lactis HN019 can be an efficient and side-effect-free adjunct strategy in the treatment of generalized gingivitis.

• Publisher: Springer Nature B.V
• Subject: Clinical trials / Cytokines / Dentistry / Disease prevention / Gingival index / Gingivitis / IL-1β / Inflammation / Interleukin 8 / Monocyte chemoattractant protein 1 / Oral administration / Patients / Placebos / Plaque index / Probiotics / Software