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MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels
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MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels
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Journal Article
MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels
2019
Overview
The mechanisms behind carbon dioxide (CO
2
) dependency in non-autotrophic bacterial isolates are unclear. Here we show that the
Staphylococcus aureus mpsAB
operon, known to play a role in membrane potential generation, is crucial for growth at atmospheric CO
2
levels. The genes
mpsAB
can complement an
Escherichia coli
carbonic anhydrase (CA) mutant, and CA from
E. coli
can complement the
S. aureus
delta-
mpsABC
mutant. In comparison with the wild type,
S. aureus mps
mutants produce less hemolytic toxin and are less virulent in animal models of infection. Homologs of
mpsA
and
mpsB
are widespread among bacteria and are often found adjacent to each other on the genome. We propose that MpsAB represents a dissolved inorganic carbon transporter, or bicarbonate concentrating system, possibly acting as a sodium bicarbonate cotransporter.
The mechanisms behind CO
2
dependency in non-autotrophic bacterial isolates are unclear. Here the authors show that the
Staphylococcus aureus mpsAB
operon is crucial for growth at atmospheric CO
2
levels, and provide evidence indicating that MpsAB represents a bicarbonate concentrating system.
