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Engineering redox balance through cofactor systems
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Journal Article
Engineering redox balance through cofactor systems
2014
Overview
•Redox balance is achieved through three cofactor systems.•Synthetic balance reshapes the whole-cell response to redox balance.•Future research on redox balance will enable advancements in cofactor engineering.
Redox balance plays an important role in the production of enzymes, pharmaceuticals, and chemicals. To meet the demands of industrial production, it is desirable that microbes maintain a maximal carbon flux towards target metabolites with no fluctuations in redox. This requires functional cofactor systems that support dynamic homeostasis between different redox states or functional stability in a given redox state. Redox balance can be achieved by improving the self-balance of a cofactor system, regulating the substrate balance of a cofactor system, and engineering the synthetic balance of a cofactor system. This review summarizes how cofactor systems can be manipulated to improve redox balance in microbes.
Publisher
Elsevier Ltd,Cell Press,Elsevier Limited
Subject
/ Biological and medical sciences
/ carbon
/ drugs
/ Enzymes
/ Escherichia coli - enzymology
/ Escherichia coli - metabolism
/ Fundamental and applied biological sciences. Psychology
/ Genomes
/ Glycerol
/ Saccharomyces cerevisiae - enzymology
/ Saccharomyces cerevisiae - genetics
