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Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients
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Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients
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Journal Article
Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients
2021
Overview
Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer, C-reactive protein (CRP), ferritin, cardiac troponin I, interleukin-6 (IL-6) levels were measured on day 1, day 7, day 14 and day 28. All hospitalized patients were SARS-CoV-2 positive on admission, while all ambulatory patients were SARS-CoV-2 positive at recruitment. Hospitalized patients had higher D-dimer, CRP and ferritin, cardiac troponin I and IL-6 levels than ambulatory patients (
p
< 0.001,
p
< 0.001,
p
= 0.016,
p
= 0.035,
p
= 0.002 respectively). Hospitalized patients experienced significant decreases in CRP, ferritin and IL-6 levels from admission to recovery (
p
< 0.001,
p
= 0.025, and
p
= 0.001 respectively). Cardiac troponin I levels were high during the acute phase in both hospitalized and ambulatory patients, indicating a potential myocardial injury. In summary, D-dimer, CRP, ferritin, cardiac troponin I, IL-6 are predictive laboratory markers and can largely determine the clinical course of COVID-19, in particular the prognosis of critically ill COVID-19 patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
