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Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

by Sica, Simona , Carella, Angelo M , Döhner, Konstanze , Divona, Mariadomenica , Ciceri, Fabio , Platzbecker, Uwe , von Lilienfeld-Toal, Marie , Levis, Alessandro , Döhner, Hartmut , Kropp, Maria Grazia , Sauer, Michaela , Wattad, Mohammed , Hänel, Matthias , Venditti, Adriano , Salih, Helmut R , Ehninger, Gerhard , Cerqui, Elisa , Morra, Enrica , Luppi, Mario , Amadori, Sergio , Melillo, Lorella , Schmitz, Norbert , Lo-Coco, Francesco , Fiedler, Walter , Brandts, Christian H , Avvisati, Giuseppe , Fazi, Paola , Hertenstein, Bernd , Cicconi, Laura , Link, Hartmut , Finizio, Olimpia , Ganser, Arnold , Orlando, Sonia Maria , Vignetti, Marco , Rambaldi, Alessandro , Cazzola, Mario , Ferrara, Felicetto , Di Bona, Eros , Lübbert, Michael , Thiede, Christian , Schlenk, Richard F , Iacobelli, Simona , Fabbiano, Francesco , Mandelli, Franco , Specchia, Giorgina , Breccia, Massimo , Fioritoni, Giuseppe , La Nasa, Giorgio

in Acute promyeloid leukemia / Adult / Aged / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Arsenic / Arsenic trioxide / Arsenicals - adverse effects / Arsenicals - therapeutic use / Biological and medical sciences / Chemotherapy / Consolidation / Consolidation Chemotherapy / Disease-Free Survival / Drug therapy / Female / General aspects / Hematologic and hematopoietic diseases / Humans / Induction Chemotherapy / Induction therapy / Leukemia / Leukemia, Promyelocytic, Acute - drug therapy / Leukemia, Promyelocytic, Acute - genetics / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Maintenance Chemotherapy / Male / Medical sciences / Middle Aged / Neutropenia - chemically induced / Oxides - adverse effects / Oxides - therapeutic use / Patients / Pharmaceutical industry / Promyeloid leukemia / Remission / Retinoic acid / Thrombocytopenia - chemically induced / Toxicity / Tretinoin - adverse effects / Tretinoin - therapeutic use / Young Adult

2013

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2013

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2013

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Journal Article

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

Sica, Simona,

Carella, Angelo M,

Döhner, Konstanze,

Divona, Mariadomenica,

Ciceri, Fabio,

Platzbecker, Uwe,

von Lilienfeld-Toal, Marie,

Levis, Alessandro,

Döhner, Hartmut,

Kropp, Maria Grazia,

Sauer, Michaela,

Wattad, Mohammed,

Hänel, Matthias,

Venditti, Adriano,

Salih, Helmut R,

Ehninger, Gerhard,

Cerqui, Elisa,

Morra, Enrica,

Luppi, Mario,

Amadori, Sergio,

Melillo, Lorella,

Schmitz, Norbert,

Lo-Coco, Francesco,

Fiedler, Walter,

Brandts, Christian H,

Avvisati, Giuseppe,

Fazi, Paola,

Hertenstein, Bernd,

Cicconi, Laura,

Link, Hartmut,

Finizio, Olimpia,

Ganser, Arnold,

Orlando, Sonia Maria,

Vignetti, Marco,

Rambaldi, Alessandro,

Cazzola, Mario,

Ferrara, Felicetto,

Di Bona, Eros,

Lübbert, Michael,

Thiede, Christian,

Schlenk, Richard F,

Iacobelli, Simona,

Fabbiano, Francesco,

Mandelli, Franco,

Specchia, Giorgina,

Breccia, Massimo,

Fioritoni, Giuseppe,

La Nasa, Giorgio

2013

Overview

All- trans retinoic acid (ATRA) plus arsenic trioxide was found to be noninferior to ATRA plus chemotherapy, and less toxic, in the treatment of acute promyelocytic leukemia. This is an early example of a curative therapy for acute leukemia without chemotherapy. Acute promyelocytic leukemia (APL) has become a highly curable disease with contemporary treatment, which consists of all- trans retinoic acid (ATRA) and anthracycline-based chemotherapy. 1 , 2 As reported in several large multicenter trials, this combination results in overall remission rates of up to 95% and cure rates now exceeding 80%. 3 – 11 Thus, the combination of ATRA and chemotherapy is currently considered the standard of care for newly diagnosed APL. 12 Arsenic trioxide is also highly effective in the treatment of APL. Early studies conducted in China and the United States showed that this agent can induce sustained molecular remission when used as . . .

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Publisher

Massachusetts Medical Society

Subject

Acute promyeloid leukemia

/ Adult

/ Aged

/ Antineoplastic Combined Chemotherapy Protocols - adverse effects

/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use

/ Arsenic

/ Arsenic trioxide