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The Candida albicans KRE9 Gene is required for Cell Wall β -1,6-glucan Synthesis and is Essential for Growth on Glucose
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The Candida albicans KRE9 Gene is required for Cell Wall β -1,6-glucan Synthesis and is Essential for Growth on Glucose
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Journal Article
The Candida albicans KRE9 Gene is required for Cell Wall β -1,6-glucan Synthesis and is Essential for Growth on Glucose
1998
Overview
We have isolated CaKRE9, a gene from Candida albicans, that is a functional homologue of the Saccharomyces cerevisiae KRE9 gene involved in β -1,6-glucan synthesis. Disruption of the CaKRE9 gene in C. albicans shows that CaKre9p is required for the synthesis or assembly of this fungal polymer. Homozygous null disruptants of CaKRE9 grow poorly on galactose and fail to form hyphae in serum, and, in growth medium containing glucose, the gene is essential. Thus, the CaKRE9 gene product is a potentially useful candidate as a target for fungal-specific drugs.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences,National Academy of Sciences,The National Academy of Sciences
Subject
/ Candida albicans - growth & development
/ Candida albicans - metabolism
/ Carbon
/ Genes
/ Genomics
/ Glucans
/ Glucose
/ Hyphae
/ Mutation
/ Polymers
/ Proteins
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae - growth & development
/ Saccharomyces cerevisiae - metabolism
/ Saccharomyces cerevisiae Proteins
/ Sequence Homology, Amino Acid
/ Yeast
/ Yeasts
