Journal Article

Efficacy and safety of hyperthermic intraperitoneal intraoperative chemotherapy plus surgery in advanced ovarian cancer patients

Yanan, Chang, Yaxin, Xu, Ting, Liu, Li, Cao Wei, Hong, Chen

2025

Overview

Objective This study aimed to evaluate the efficacy and safety of hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC) in patients with advanced ovarian cancer. Methods A total of 200 patients with advanced ovarian cancer were enrolled in this retrospective study and randomly allocated to two groups (research registry number: 11353). On the first day after abdominal closure, routine treatment was performed in the non-HIPEC group, whereas HIPEC was performed in the HIPEC group. The surgical outcomes, overall survival, progression-free survival, side effects, and quality of life of patients were compared between the two groups, and the risk factors for overall survival and progression-free survival were analyzed. Results The basic information of the patients showed no significant difference between the two groups (p > 0.05). There was no significant difference in the time from surgery to first flatus, postoperative hospital stay, abdominal pain, bleeding, leakage, or other blood indices between the two groups (p > 0.05); however, the symptoms of ileus and pelvic abscess appeared more frequently in the non-HIPEC group (p < 0.05). HIPEC, tumor size, N stage, T stage, and vascular invasion were significant indicators, while HIPEC, tumor size, vascular invasion, N stage, and T stage were independent prognostic factors. The 3-year survival rate of the HIPEC group (42%) was higher than that of the non-HIPEC group (21%) (p < 0.001). The progression-free survival curve of the HIPEC group was superior to that of the non-HIPEC group (p < 0.001), and the recurrence rate of the HIPEC group (25%) was lower than that of the non-HIPEC group (49%) (p < 0.001). Conclusions HIPEC can reduce the possibility of perioperative complications such as intestinal obstruction and pelvic abscess, and the overall survival and progression-free survival curves were better in the HIPEC group.

• Publisher: SAGE Publications,Sage Publications Ltd,SAGE Publishing
• Subject: Abscesses / Adult / Aged / Chemotherapy / Combined Modality Therapy / Cytoreduction Surgical Procedures / Female / Humans / Hyperthermic Intraperitoneal Chemotherapy - adverse effects / Hyperthermic Intraperitoneal Chemotherapy - methods / Intraoperative Care / Medical prognosis / Middle Aged / Ovarian cancer / Ovarian Neoplasms - drug therapy / Ovarian Neoplasms - mortality / Ovarian Neoplasms - pathology / Ovarian Neoplasms - surgery / Ovarian Neoplasms - therapy / Progression-Free Survival / Quality of Life / Randomised Clinical Trial / Retrospective Studies / Surgical outcomes / Treatment Outcome