Journal Article

Veterinary Clinics as Reservoirs for Pseudomonas aeruginosa: A Neglected Pathway in One Health Surveillance

Bouari, Cosmina Maria, Manchon, Alice Mathilde, Nadăş, George Cosmin, Fiț, Nicodim Iosif

2025

Overview

Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen with significant clinical relevance in both human and veterinary medicine. Despite its well-documented role in hospital-acquired infections in human healthcare settings, its persistence and transmission within veterinary clinics remain underexplored. This review highlights the overlooked status of veterinary facilities as environmental reservoirs and amplification points for multidrug-resistant (MDR) P. aeruginosa, emphasizing their relevance to One Health surveillance. We examine the bacterium’s environmental survival strategies, including biofilm formation, resistance to disinfectants, and tolerance to nutrient-poor conditions that facilitate the long-term colonization of moist surfaces, drains, medical equipment, and plumbing systems. Common transmission vectors are identified, including asymptomatic animal carriers, contaminated instruments, and the hands of veterinary staff. The review synthesizes current data on antimicrobial resistance in environmental isolates, revealing frequent expression of efflux pumps and mobile resistance genes, and documents the potential for zoonotic transmission to staff and pet owners. Key gaps in environmental monitoring, infection control protocols, and genomic surveillance are identified, with a call for standardized approaches tailored to the veterinary context. Control strategies, including mechanical biofilm disruption, disinfectant cycling, effluent monitoring, and staff hygiene training, are evaluated for feasibility and impact. The article concludes with a One Health framework outlining cross-species and environmental transmission pathways. It advocates for harmonized surveillance, infrastructure improvements, and intersectoral collaboration to reduce the risk posed by MDR P. aeruginosa within veterinary clinical environments and beyond. By addressing these blind spots, veterinary facilities can become proactive partners in antimicrobial stewardship and global resistance mitigation.

• Publisher: MDPI AG,MDPI
• Subject: Animals / Antibiotics / Antimicrobial agents / Antimicrobial resistance / Antiseptics / biofilm resistance / Biofilms / Chronic illnesses / Disease control / Disease transmission / Disinfectants / Disinfection & disinfectants / Drug resistance / Drug resistance in microorganisms / Efflux / Environmental monitoring / environmental reservoirs / Epidemiology / Genetic research / Health aspects / Hospital patients / Hospitals / Hygiene / Infection / Infections / Medical equipment / Multidrug resistance / Nosocomial infections / nosocomial pathogens / One Health surveillance / Opportunist infection / Pathogenesis / Pathogens / Pets / Physiological apparatus / Pseudomonas aeruginosa / Review / Surveillance / Telemedicine / Vectors / Ventilators / veterinary infection control / Veterinary medicine / Veterinary services / Zoonoses